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Molecules 2013, 18(12), 15000-15018; doi:10.3390/molecules181215000

Synthesis and Biological Activity of 3-[Phenyl(1,3-thiazol-2-yl)-amino]propanoic Acids and Their Derivatives

1
Department of Organic Chemistry, Kaunas University of Technology, Radvilėnų pl. 19, LT-50254 Kaunas, Lithuania
2
Lithuanian University of Health Sciences, Veterinary Academy, Tilžės 18, LT-47181 Kaunas, Lithuania
3
Department of Food Technology, Kaunas University of Technology, Radvilėnų pl. 19, LT-50254 Kaunas, Lithuania
4
Lithuanian Research Centre for Agriculture and Forestry, Rumokai Experimental Station, Klausučiai, 70462 Vilkaviškis Distr., Lithuania
5
Institute of Agricultural and Food Sciences, Aleksandras Stulginskis University, Studentų g. 11, LT-53361 Akademija, Kaunor., Lithuania
*
Author to whom correspondence should be addressed.
Received: 24 October 2013 / Revised: 3 December 2013 / Accepted: 3 December 2013 / Published: 5 December 2013
(This article belongs to the Section Organic Synthesis)
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Abstract

New N,N-disubstituted β-amino acids and their derivatives with thiazole, aromatic, and heterocyclic substituents were synthesized from N-phenyl-N-thiocarbamoyl-β-alanine by the Hantzsch method; derivatives with hydrazone fragments were also obtained. Some of the synthesized compounds exhibited discrete antimicrobial activity, and 3-[(4-oxo-4,5-dihydro-1,3-thiazol-2-yl)(phenyl)amino]propanoic acid was found to promote rapeseed growth and to increase seed yield and oil content. View Full-Text
Keywords: N-phenyl-N-thiocarbamoyl-β-alanine; Hantzsch synthesis; thiazole; hydrazone; biological activity N-phenyl-N-thiocarbamoyl-β-alanine; Hantzsch synthesis; thiazole; hydrazone; biological activity
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This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Mickevičius, V.; Voskienė, A.; Jonuškienė, I.; Kolosej, R.; Šiugždaitė, J.; Venskutonis, P.R.; Kazernavičiūtė, R.; Brazienė, Z.; Jakienė, E. Synthesis and Biological Activity of 3-[Phenyl(1,3-thiazol-2-yl)-amino]propanoic Acids and Their Derivatives. Molecules 2013, 18, 15000-15018.

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