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Molecules 2013, 18(12), 15000-15018; doi:10.3390/molecules181215000
Article

Synthesis and Biological Activity of 3-[Phenyl(1,3-thiazol-2-yl)-amino]propanoic Acids and Their Derivatives

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Received: 24 October 2013 / Revised: 3 December 2013 / Accepted: 3 December 2013 / Published: 5 December 2013
(This article belongs to the Section Organic Synthesis)
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Abstract

New N,N-disubstituted β-amino acids and their derivatives with thiazole, aromatic, and heterocyclic substituents were synthesized from N-phenyl-N-thiocarbamoyl-β-alanine by the Hantzsch method; derivatives with hydrazone fragments were also obtained. Some of the synthesized compounds exhibited discrete antimicrobial activity, and 3-[(4-oxo-4,5-dihydro-1,3-thiazol-2-yl)(phenyl)amino]propanoic acid was found to promote rapeseed growth and to increase seed yield and oil content.
Keywords: N-phenyl-N-thiocarbamoyl-β-alanine; Hantzsch synthesis; thiazole; hydrazone; biological activity N-phenyl-N-thiocarbamoyl-β-alanine; Hantzsch synthesis; thiazole; hydrazone; biological activity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Mickevičius, V.; Voskienė, A.; Jonuškienė, I.; Kolosej, R.; Šiugždaitė, J.; Venskutonis, P.R.; Kazernavičiūtė, R.; Brazienė, Z.; Jakienė, E. Synthesis and Biological Activity of 3-[Phenyl(1,3-thiazol-2-yl)-amino]propanoic Acids and Their Derivatives. Molecules 2013, 18, 15000-15018.

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