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Molecules 2013, 18(12), 14989-14999; doi:10.3390/molecules181214989
Article

Effects of Aronia melanocarpa Constituents on Biofilm Formation of Escherichia coli and Bacillus cereus

1,* , 2
, 3
, 1
, 1
 and 1
1 Department of Pharmaceutical Chemistry, School of Pharmacy, University of Oslo, P.O. Box 1068, Blindern, Oslo N-0316, Norway 2 Laboratory for Microbial Dynamics and Department of Pharmaceutical Biosciences, School of Pharmacy, University of Oslo, P.O. Box 1068, Blindern, Oslo N-0316, Norway 3 PlantChem, Særheim Research Center, N-4353 Klepp Station, Norway
* Author to whom correspondence should be addressed.
Received: 8 October 2013 / Revised: 30 November 2013 / Accepted: 2 December 2013 / Published: 5 December 2013
(This article belongs to the Section Metabolites)
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Abstract

Many bacteria growing on surfaces form biofilms. Adaptive and genetic changes of the microorganisms in this structure make them resistant to antimicrobial agents. Biofilm-forming organisms on medical devices can pose serious threats to human health. Thus, there is a need for novel prevention and treatment strategies. This study aimed to evaluate the ability of Aronia melanocarpa extracts, subfractions and compounds to prevent biofilm formation and to inhibit bacterial growth of Escherichia coli and Bacillus cereus in vitro. It was found that several aronia substances possessed anti-biofilm activity, however, they were not toxic to the species screened. This non-toxic inhibition may confer a lower potential for resistance development compared to conventional antimicrobials.
Keywords: Aronia melanocarpa; biofilm formation; Escherichia coli; Bacillus cereus; flavonoids Aronia melanocarpa; biofilm formation; Escherichia coli; Bacillus cereus; flavonoids
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Bräunlich, M.; Økstad, O.A.; Slimestad, R.; Wangensteen, H.; Malterud, K.E.; Barsett, H. Effects of Aronia melanocarpa Constituents on Biofilm Formation of Escherichia coli and Bacillus cereus. Molecules 2013, 18, 14989-14999.

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