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Molecules 2013, 18(12), 14585-14596; doi:10.3390/molecules181214585
Article

Astataricusones A–D and Astataricusol A, Five New Anti-HBV Shionane-Type Triterpenes from Aster tataricus L. f.

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Received: 9 October 2013 / Revised: 13 November 2013 / Accepted: 15 November 2013 / Published: 25 November 2013
(This article belongs to the Section Metabolites)
Download PDF [388 KB, 18 June 2014; original version 18 June 2014]

Abstract

Five new shionane-type triterpenes, astataricusones A–D (compounds 14) and astataricusol A (5), together with one known shionane-type triterpene 6 were obtained from the roots and rhizomes of Aster tataricus L. f. Their structures were elucidated on the basis of spectroscopic data, mainly NMR and MS data. The absolute configurations of 1 and 4 was determined by single crystal X-ray diffraction and CD analysis. Compound 2 showed inhibitory activity on HBsAg secretion with an IC50 value of 23.5 μM, while 2 and 6 showed inhibitory activities on HBeAg secretion with IC50 values of 18.6 and 40.5 μM, and cytotoxicity on HepG 2.2.15 cells with CC50 values of 172.4 and 137.7 μM, respectively. Compounds 2 and 6 also exhibited inhibitory activities on HBV DNA replication with IC50 values of 2.7 and 30.7 μM, respectively.
Keywords: Aster tataricus; shionane-type triterpenes; astataricusones A–D; astataricusol A; anti-HBV Aster tataricus; shionane-type triterpenes; astataricusones A–D; astataricusol A; anti-HBV
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Zhou, W.-B.; Zeng, G.-Z.; Xu, H.-M.; He, W.-J.; Tan, N.-H. Astataricusones A–D and Astataricusol A, Five New Anti-HBV Shionane-Type Triterpenes from Aster tataricus L. f.. Molecules 2013, 18, 14585-14596.

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