Molecules 2013, 18(11), 14340-14348; doi:10.3390/molecules181114340
Communication

Antibacterial Activity of Glucomoringin Bioactivated with Myrosinase against Two Important Pathogens Affecting the Health of Long-Term Patients in Hospitals

1 IRCCS Centro Neurolesi "Bonino-Pulejo", Via Provinciale Palermo, S.S.113, Contrada Casazza, Messina 98124, Italy 2 Consiglio per la Ricerca e la sperimentazione in Agricoltura, Centro di Ricerca per le Colture Industriali (CRA-CIN), Via Di Corticella 133, Bologna 40128, Italy
* Authors to whom correspondence should be addressed.
Received: 25 October 2013; in revised form: 8 November 2013 / Accepted: 11 November 2013 / Published: 20 November 2013
(This article belongs to the Section Natural Products)
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Abstract: Glucosinolates (GLs) are natural compounds present in species of the order Brassicales and precursors of bioactive isothiocyanates (ITCs). In the recent years, they have been studied mainly for their chemopreventive as well as novel chemotherapeutics properties. Among them 4-(α-L-rhamnosyloxy)benzyl glucosinolate (glucomoringin; GMG), purified from seeds of Moringa oleifera Lam., a plant belonging to the Moringaceae family, represents an uncommon member of the GL family with peculiar characteristics. This short communication reports new evidences about the properties of GMG and presents a new innovative utilization of the molecule. The bioactivation of GMG by myrosinase enzyme just before treatment, permits to maximize the power of the final product of the reaction, which is the 4-(α-L-rhamnosyloxy)benzyl isothiocyanate (GMG-ITC). We tested the antibiotic activity of this latter compound on two strains of pathogens affecting the health of patients in hospital, namely Staphylococcus aureus and Enterococcus casseliflavus, and on the yeast Candida albicans. Results show that the sensibility of S. aureus BAA-977 strain and E. casseliflavus to GMG-ITC treatment reveals an important possible application of this molecule in the clinical care of patients, more and more often resistant to traditional therapies.
Keywords: glucomoringin; isothiocyanate; Moringa oleifera; antibiotic activity; Staphylococcus aureus; Enterococcus casseliflavus

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MDPI and ACS Style

Galuppo, M.; Nicola, G.R.D.; Iori, R.; Dell'Utri, P.; Bramanti, P.; Mazzon, E. Antibacterial Activity of Glucomoringin Bioactivated with Myrosinase against Two Important Pathogens Affecting the Health of Long-Term Patients in Hospitals. Molecules 2013, 18, 14340-14348.

AMA Style

Galuppo M, Nicola GRD, Iori R, Dell'Utri P, Bramanti P, Mazzon E. Antibacterial Activity of Glucomoringin Bioactivated with Myrosinase against Two Important Pathogens Affecting the Health of Long-Term Patients in Hospitals. Molecules. 2013; 18(11):14340-14348.

Chicago/Turabian Style

Galuppo, Maria; Nicola, Gina R.D.; Iori, Renato; Dell'Utri, Pia; Bramanti, Placido; Mazzon, Emanuela. 2013. "Antibacterial Activity of Glucomoringin Bioactivated with Myrosinase against Two Important Pathogens Affecting the Health of Long-Term Patients in Hospitals." Molecules 18, no. 11: 14340-14348.

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