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Molecules 2013, 18(11), 14105-14121; doi:10.3390/molecules181114105
Article

Chemical Composition and Antioxidant Activity of Tánara Ótó (Dracocephalum palmatum Stephan), a Medicinal Plant Used by the North-Yakutian Nomads

1,* , 2
, 3
 and 3,4,5
1 Institute of General and Experimental Biology, Siberian Division, Russian Academy of Science, Sakh'yanovoy str., 6, Ulan-Ude 670047, Russia 2 Department of Biochemistry and Biotechnology, North-Eastern Federal University, 58 Belinsky Str., Yakutsk 677-027, Russia 3 Department of Biology, North-Eastern Federal University, 58 Belinsky Str., Yakutsk 677-027, Russia 4 Department of Molecular Biology, Pusan National University, Pusan 609-735, Korea 5 Institute of Botany, Azerbaijan National Academy of Sciences, Baku AZ 1073, Azerbaijan
* Author to whom correspondence should be addressed.
Received: 11 October 2013 / Revised: 6 November 2013 / Accepted: 8 November 2013 / Published: 14 November 2013
(This article belongs to the Section Metabolites)
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Abstract

Dracocephalum palmatum Stephan (Lamiaceae) is a medicinal plant used by the North-Yakutian nomads. From the crude ethanolic extract of the aerial parts of this plant, 23 compounds (phenylpropanoids, coumarins, flavonoids, and triterpenes) were isolated. Among these, eight compounds (salvianolic acid B, caftaric acid, cichoric acid, umbelliferone, aesculetin, apigenin-7-O-β-d-glucuronopyranoside, isorhoifolin, and luteolin-4'-O-β-d-glucopyranoside) were detected for the first time in the genus Dracocephalum. Their structures were elucidated based on chemical and spectral data. The levels of most of the compounds detected in the cultivated sample were close to that of the wild sample, indicating the reproducibility of the biologically active compounds of D. palmatum through cultivation. Investigation into the biological activity of D. palmatum under in vitro conditions demonstrated that its extracts have a strong antioxidant effect due to the presence of high concentrations of phenolic compounds.
Keywords: Dracocephalum palmatum Stephan; Lamiaceae; North-Yakutian nomads; flavonoids; phenylpropanoids; antioxidant activity Dracocephalum palmatum Stephan; Lamiaceae; North-Yakutian nomads; flavonoids; phenylpropanoids; antioxidant activity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Olennikov, D.N.; Chirikova, N.K.; Okhlopkova, Z.M.; Zulfugarov, I.S. Chemical Composition and Antioxidant Activity of Tánara Ótó (Dracocephalum palmatum Stephan), a Medicinal Plant Used by the North-Yakutian Nomads. Molecules 2013, 18, 14105-14121.

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