Molecules 2013, 18(11), 14096-14104; doi:10.3390/molecules181114096
Article

Bioactive Quinic Acid Derivatives from Ageratina adenophora

1, 2, 1,3, 4, 2, 1,3, 1,3, 1 and 1,* email
Received: 22 September 2013; in revised form: 23 October 2013 / Accepted: 28 October 2013 / Published: 14 November 2013
(This article belongs to the Section Natural Products)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: A novel quinic acid derivative, 5-O-trans-o-coumaroylquinic acid methyl ester (1), together with three known ones, chlorogenic acid methyl ester (2), macranthoin F (3) and macranthoin G (4), were isolated from the aerial parts of the invasive plant Ageratina adenophora (Spreng.). The structure of new compound 1 was elucidated on the basis of extensive spectroscopic analysis, including 1D- and 2D-NMR techniques. Compounds 24 were isolated from plant A. adenophora for the first time. All the compounds showed in vitro antibacterial activity toward five assayed bacterial strains, especially 3 and 4, which showed in vitro antibacterial activity against Salmonella enterica with MIC values of 7.4 and 14.7 μM, respectively. Compound 1 was further found to display in vitro anti-fungal activity against spore germination of Magnaporthe grisea with an IC50 value 542.3 µM. These four compounds were also tested for their antioxidant activity against DPPH (1,1-diphenyl-2-picrylhydrazyl) radical.
Keywords: Ageratina adenophora; qunic acid; antimicrobial activity; radical scavenging capacity; DPPH
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MDPI and ACS Style

Zhang, M.; Liu, W.-X.; Zheng, M.-F.; Xu, Q.-L.; Wan, F.-H.; Wang, J.; Lei, T.; Zhou, Z.-Y.; Tan, J.-W. Bioactive Quinic Acid Derivatives from Ageratina adenophora. Molecules 2013, 18, 14096-14104.

AMA Style

Zhang M, Liu W-X, Zheng M-F, Xu Q-L, Wan F-H, Wang J, Lei T, Zhou Z-Y, Tan J-W. Bioactive Quinic Acid Derivatives from Ageratina adenophora. Molecules. 2013; 18(11):14096-14104.

Chicago/Turabian Style

Zhang, Mei; Liu, Wan-Xue; Zheng, Meng-Fei; Xu, Qiao-Lin; Wan, Fang-Hao; Wang, Jing; Lei, Ting; Zhou, Zhong-Yu; Tan, Jian-Wen. 2013. "Bioactive Quinic Acid Derivatives from Ageratina adenophora." Molecules 18, no. 11: 14096-14104.

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