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Bioactive Quinic Acid Derivatives from Ageratina adenophora
AbstractA novel quinic acid derivative, 5-O-trans-o-coumaroylquinic acid methyl ester (1), together with three known ones, chlorogenic acid methyl ester (2), macranthoin F (3) and macranthoin G (4), were isolated from the aerial parts of the invasive plant Ageratina adenophora (Spreng.). The structure of new compound 1 was elucidated on the basis of extensive spectroscopic analysis, including 1D- and 2D-NMR techniques. Compounds 2–4 were isolated from plant A. adenophora for the first time. All the compounds showed in vitro antibacterial activity toward five assayed bacterial strains, especially 3 and 4, which showed in vitro antibacterial activity against Salmonella enterica with MIC values of 7.4 and 14.7 μM, respectively. Compound 1 was further found to display in vitro anti-fungal activity against spore germination of Magnaporthe grisea with an IC50 value 542.3 µM. These four compounds were also tested for their antioxidant activity against DPPH (1,1-diphenyl-2-picrylhydrazyl) radical.
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Zhang, M.; Liu, W.-X.; Zheng, M.-F.; Xu, Q.-L.; Wan, F.-H.; Wang, J.; Lei, T.; Zhou, Z.-Y.; Tan, J.-W. Bioactive Quinic Acid Derivatives from Ageratina adenophora. Molecules 2013, 18, 14096-14104.View more citation formats
Zhang M, Liu W-X, Zheng M-F, Xu Q-L, Wan F-H, Wang J, Lei T, Zhou Z-Y, Tan J-W. Bioactive Quinic Acid Derivatives from Ageratina adenophora. Molecules. 2013; 18(11):14096-14104.Chicago/Turabian Style
Zhang, Mei; Liu, Wan-Xue; Zheng, Meng-Fei; Xu, Qiao-Lin; Wan, Fang-Hao; Wang, Jing; Lei, Ting; Zhou, Zhong-Yu; Tan, Jian-Wen. 2013. "Bioactive Quinic Acid Derivatives from Ageratina adenophora." Molecules 18, no. 11: 14096-14104.