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Molecules 2013, 18(11), 14096-14104; doi:10.3390/molecules181114096
Article

Bioactive Quinic Acid Derivatives from Ageratina adenophora

1, 2, 1,3, 4, 2, 1,3, 1,3, 1 and 1,*
1 Key Laboratory of Plant Resources Conservation and Sustainable Utilization, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650, China 2 State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing 100193, China 3 University of Chinese Academy of Sciences, Beijing 100049, China 4 Biotechnology Division, Guangdong Academy of Forestry, Guangzhou 510520, China
* Author to whom correspondence should be addressed.
Received: 22 September 2013 / Revised: 23 October 2013 / Accepted: 28 October 2013 / Published: 14 November 2013
(This article belongs to the Section Natural Products)
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Abstract

A novel quinic acid derivative, 5-O-trans-o-coumaroylquinic acid methyl ester (1), together with three known ones, chlorogenic acid methyl ester (2), macranthoin F (3) and macranthoin G (4), were isolated from the aerial parts of the invasive plant Ageratina adenophora (Spreng.). The structure of new compound 1 was elucidated on the basis of extensive spectroscopic analysis, including 1D- and 2D-NMR techniques. Compounds 24 were isolated from plant A. adenophora for the first time. All the compounds showed in vitro antibacterial activity toward five assayed bacterial strains, especially 3 and 4, which showed in vitro antibacterial activity against Salmonella enterica with MIC values of 7.4 and 14.7 μM, respectively. Compound 1 was further found to display in vitro anti-fungal activity against spore germination of Magnaporthe grisea with an IC50 value 542.3 µM. These four compounds were also tested for their antioxidant activity against DPPH (1,1-diphenyl-2-picrylhydrazyl) radical.
Keywords: Ageratina adenophora; qunic acid; antimicrobial activity; radical scavenging capacity; DPPH Ageratina adenophora; qunic acid; antimicrobial activity; radical scavenging capacity; DPPH
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Zhang, M.; Liu, W.-X.; Zheng, M.-F.; Xu, Q.-L.; Wan, F.-H.; Wang, J.; Lei, T.; Zhou, Z.-Y.; Tan, J.-W. Bioactive Quinic Acid Derivatives from Ageratina adenophora. Molecules 2013, 18, 14096-14104.

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