Next Article in Journal
Previous Article in Journal
Molecules 2013, 18(11), 14070-14084; doi:10.3390/molecules181114070
Article

Design, Synthesis and Cytotoxic Activities of Novel Aliphatic Amino-Substituted Flavonoids

1,* , 2
, 3
 and 1,*
Received: 29 September 2013; in revised form: 31 October 2013 / Accepted: 4 November 2013 / Published: 13 November 2013
Download PDF [272 KB, uploaded 18 June 2014]
Abstract: A series of flavonoids 9af, 13b, 13d, 13e and 14af bearing diverse aliphatic amino moieties were designed, synthesized and evaluated for their cytotoxic activities against the ECA-109, A-549, HL-60, and PC-3 cancer cell lines. Most of the compounds exhibited moderate to good activities. The structure-activity relationships were studied, revealing that the chalcone skeleton is the most preferable for cytotoxic activities. Chalcone 9d was the most promising compound due to its high potency against the examined cancer cell lines (its IC50 values against ECA-109, A549, HL-60 and PC-3 cells were 1.0, 1.5, 0.96 and 3.9 μM, respectively).
Keywords: flavonoid; chalcone; synthesis; cytotoxic activity flavonoid; chalcone; synthesis; cytotoxic activity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Export to BibTeX |
EndNote


MDPI and ACS Style

Liu, G.; Ge, Z.; Zhao, M.; Zhou, Y. Design, Synthesis and Cytotoxic Activities of Novel Aliphatic Amino-Substituted Flavonoids. Molecules 2013, 18, 14070-14084.

AMA Style

Liu G, Ge Z, Zhao M, Zhou Y. Design, Synthesis and Cytotoxic Activities of Novel Aliphatic Amino-Substituted Flavonoids. Molecules. 2013; 18(11):14070-14084.

Chicago/Turabian Style

Liu, Guannan; Ge, Zhen; Zhao, Mengdan; Zhou, Yifeng. 2013. "Design, Synthesis and Cytotoxic Activities of Novel Aliphatic Amino-Substituted Flavonoids." Molecules 18, no. 11: 14070-14084.


Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert