Molecules 2013, 18(11), 13979-13991; doi:10.3390/molecules181113979
Article

The Synthesis and Characterization of Hydroxyapatite-β-Alanine Modified by Grafting Polymerization of γ-Benzyl-L-glutamate-N-carboxyanhydride

1, 2, 1, 1 and 1,* email
Received: 14 October 2013; in revised form: 8 November 2013 / Accepted: 8 November 2013 / Published: 13 November 2013
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: In this study, hydroxyapatite (HAP) was surface-modified by the addition of β-alanine (β-Ala), and the ring-opening polymerization of γ-benzyl-L-glutamate-N-carboxy-anhydride (BLG-NCA) was subsequently initiated. HAP containing surface poly-γ-benzyl-L-glutamates (PBLG) was successfully prepared in this way. With the increase of PBLG content in HAP-PBLG, the solubility of HAP-PBLG increased gradually and it was ultimately soluble in chloroform. HAP-PLGA with surface carboxyl groups was obtained by the catalytic hydrogenation of HAP-PBLG. In the process of HAP modification, the morphology changes from rod to sheet and from flake to needle. The effect of BLG-NCA concentration on the character of hydroxyapatite-β-alanine-poly(γ-benzyl-L-glutamate) (HAP-PBLG) was investigated. The existence of amino acids on the HAP surfaces was confirmed in the resulting Fourier transform infrared (FTIR) spectra. The resulting powder X-ray diffraction patterns indicated that the crystallinity of HAP decreased when the ratio of BLG-NCA/HAP-NH2 increased to 20/1. Transmission electron microscopy (TEM) indicated that the particle size of HAP-PBLG decreased significantly and that the resulting particles appeared less agglomerated relative to that of the HAP-NH2 crystals. Furthermore, 1H-NMR spectra and FTIR spectra revealed that hydroxyapatite-β-alanine-poly (L-glutamic acid) (HAP-PLGA) was able to successfully bear carboxylic acid groups on its side chains.
Keywords: hydroxyapatite; β-alanine; γ-benzyl-L-glutamate-N-carboxyanhydride; surface modification; hydroxyapatite-β-alanine-poly(γ-benzyl-L-glutamates)
PDF Full-text Download PDF Full-Text [553 KB, uploaded 18 June 2014 20:14 CEST]

Export to BibTeX |
EndNote


MDPI and ACS Style

Shan, Y.; Qin, Y.; Chuan, Y.; Li, H.; Yuan, M. The Synthesis and Characterization of Hydroxyapatite-β-Alanine Modified by Grafting Polymerization of γ-Benzyl-L-glutamate-N-carboxyanhydride. Molecules 2013, 18, 13979-13991.

AMA Style

Shan Y, Qin Y, Chuan Y, Li H, Yuan M. The Synthesis and Characterization of Hydroxyapatite-β-Alanine Modified by Grafting Polymerization of γ-Benzyl-L-glutamate-N-carboxyanhydride. Molecules. 2013; 18(11):13979-13991.

Chicago/Turabian Style

Shan, Yukai; Qin, Yuyue; Chuan, Yongming; Li, Hongli; Yuan, Minglong. 2013. "The Synthesis and Characterization of Hydroxyapatite-β-Alanine Modified by Grafting Polymerization of γ-Benzyl-L-glutamate-N-carboxyanhydride." Molecules 18, no. 11: 13979-13991.

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert