Effect of HT042, Herbal Formula, on Longitudinal Bone Growth in Spontaneous Dwarf Rats
AbstractHT042 is a new herbal prescription consisting of Astragalus membranaceus, Phlomis umbrosa and Eleutherococcus senticosus, which are used in Korean medicine to stimulate growth in children. We investigated the effects of HT042 on the body weight, longitudinal bone growth, and bone length in spontaneous dwarf rats (SDR). Male and female SDRs were divided into three groups: the control group (DW, 10 mL/kg/day), the recombinant human GH group (rhGH; 500 µg/kg/day), and the HT042 (100 mg/kg/day) group. Each group received the respective treatments for 10 days. Body weight was measured on day 10 of treatment. On day 8, tetracycline (20 mg/kg) was injected intraperitoneally into all individuals to form a fluorescent band on the newly synthesized bone. On day 10, femur and tibia lengths were measured using PIXImus. Body weight, longitudinal bone growth, and bone length were not affected in the HT042 group. In contrast, the rhGH group showed significantly increased body weight, longitudinal bone growth, and bone length. In conclusion, HT042 does not act through a GH-like effect to promote longitudinal bone growth. View Full-Text
Scifeed alert for new publicationsNever miss any articles matching your research from any publisher
- Get alerts for new papers matching your research
- Find out the new papers from selected authors
- Updated daily for 49'000+ journals and 6000+ publishers
- Define your Scifeed now
Kim, J.Y.; Song, M.; Lee, D.; Song, J.; Park, S.W.; Park, J.; Park, S.; Choi, H.-Y.; Kim, H. Effect of HT042, Herbal Formula, on Longitudinal Bone Growth in Spontaneous Dwarf Rats. Molecules 2013, 18, 13271-13282.
Kim JY, Song M, Lee D, Song J, Park SW, Park J, Park S, Choi H-Y, Kim H. Effect of HT042, Herbal Formula, on Longitudinal Bone Growth in Spontaneous Dwarf Rats. Molecules. 2013; 18(11):13271-13282.Chicago/Turabian Style
Kim, Ji Y.; Song, MiKyung; Lee, Donghun; Song, Jungbin; Park, Sang W.; Park, Juyeon; Park, Seungjoon; Choi, Ho-Young; Kim, Hocheol. 2013. "Effect of HT042, Herbal Formula, on Longitudinal Bone Growth in Spontaneous Dwarf Rats." Molecules 18, no. 11: 13271-13282.