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Molecules 2013, 18(11), 13260-13270; doi:10.3390/molecules181113260
Article

Isosakuranetin-5-O-rutinoside: A New Flavanone with Antidepressant Activity Isolated from Salvia elegans Vahl.

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Received: 21 August 2013 / Revised: 12 October 2013 / Accepted: 22 October 2013 / Published: 25 October 2013
(This article belongs to the Section Metabolites)
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Abstract

Ursolic acid (1) and a new flavanone, 5-O-(6-rhamnosylglucoside)-7-hydroxy-4'-methoxyflavanone (2), were isolated from the leaves of Salvia elegans Vahl. These natural products displayed antidepressant activity in mice as determined by means of a forced swimming test (FST) evaluation. Structural elucidation was carried out by chemical derivatization (acetylation) and spectroscopic analyses, such as 1H- and 13C-NMR and two-dimensional (2-D) COSY, heteronuclear multiple quantum coherence (HMQC), and heteronuclear multiple-bond correlation (HMBC) spectroscopy experiments.
Keywords: Salvia elegans; flavanone; rutinoside; isosakuranetin; NMR; ursolic acid; antidepressant activity Salvia elegans; flavanone; rutinoside; isosakuranetin; NMR; ursolic acid; antidepressant activity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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González-Cortazar, M.; Maldonado-Abarca, A.M.; Jiménez-Ferrer, E.; Marquina, S.; Ventura-Zapata, E.; Zamilpa, A.; Tortoriello, J.; Herrera-Ruiz, M. Isosakuranetin-5-O-rutinoside: A New Flavanone with Antidepressant Activity Isolated from Salvia elegans Vahl.. Molecules 2013, 18, 13260-13270.

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