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Molecules 2013, 18(11), 13260-13270; doi:10.3390/molecules181113260

Isosakuranetin-5-O-rutinoside: A New Flavanone with Antidepressant Activity Isolated from Salvia elegans Vahl.

1
Southern Biomedical Research Center, Mexican Institute of Social Security, Argentina 1, Centro 62790, Xochitepec, Morelos, Mexico
2
Chemical Research Center, Universidad Autónoma del Edo. de Morelos (UAEM), Av. Universidad 1001, Col. Chamilpa 62210, Cuernavaca, Morelos, Mexico
3
Development Center Biotic Products, Instituto Politécnico Nacional (IPN), 62761 Yautepec, Morelos, Mexico
*
Author to whom correspondence should be addressed.
Received: 21 August 2013 / Revised: 12 October 2013 / Accepted: 22 October 2013 / Published: 25 October 2013
(This article belongs to the Section Natural Products)
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Abstract

Ursolic acid (1) and a new flavanone, 5-O-(6-rhamnosylglucoside)-7-hydroxy-4'-methoxyflavanone (2), were isolated from the leaves of Salvia elegans Vahl. These natural products displayed antidepressant activity in mice as determined by means of a forced swimming test (FST) evaluation. Structural elucidation was carried out by chemical derivatization (acetylation) and spectroscopic analyses, such as 1H- and 13C-NMR and two-dimensional (2-D) COSY, heteronuclear multiple quantum coherence (HMQC), and heteronuclear multiple-bond correlation (HMBC) spectroscopy experiments.
Keywords: Salvia elegans; flavanone; rutinoside; isosakuranetin; NMR; ursolic acid; antidepressant activity Salvia elegans; flavanone; rutinoside; isosakuranetin; NMR; ursolic acid; antidepressant activity
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MDPI and ACS Style

González-Cortazar, M.; Maldonado-Abarca, A.M.; Jiménez-Ferrer, E.; Marquina, S.; Ventura-Zapata, E.; Zamilpa, A.; Tortoriello, J.; Herrera-Ruiz, M. Isosakuranetin-5-O-rutinoside: A New Flavanone with Antidepressant Activity Isolated from Salvia elegans Vahl.. Molecules 2013, 18, 13260-13270.

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