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Molecules 2013, 18(10), 12809-12819; doi:10.3390/molecules181012809

Astragaloside IV Stimulates Angiogenesis and Increases Nitric Oxide Accumulation via JAK2/STAT3 and ERK1/2 Pathway

1
First Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing 210023, China
2
Department of Cardiology, Jiangsu Province Hospital of Traditional Chinese Medicine, The Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, China
3
College of Basic Medical Science, Nanjing University of Chinese Medicine, Nanjing 210023, China
4
Department of Cardiology, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan 250011, China
*
Author to whom correspondence should be addressed.
Received: 23 August 2013 / Revised: 30 September 2013 / Accepted: 10 October 2013 / Published: 16 October 2013
(This article belongs to the Section Natural Products)
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Abstract

Astragaloside IV (AS-IV), one of the major active constituents of Astragalus membranaceus in Traditional Chinese Medicine, has been widely used to treat ischemic diseases. However, the potential mechanism is this action is unclear. In this study, we tested the hypothesis that AS-IV might promote angiogenesis through multiple signaling pathways. Our data indicate that AS-IV treatment promotes umbilical vein endothelial cells (HUVEC) proliferation, migration, and tube formation. AS-IV treatment also activates JAK2/STAT3 and ERK1/2 signaling pathways, and up-regulates endothelial nitric oxide synthase (eNOS) expression and nitric oxide (NO) production. AS-IV-induced angiogenesis in HUVECs is significantly blocked by specific kinase inhibitors. Our study indicated that AS-IV is a key regulator of NO and angiogenesis through the JAK2/STAT3 and ERK1/2 pathways, which provides a mechanistic basis for the potential use of this compound in the treatment of clinical ischemic diseases. View Full-Text
Keywords: astragaloside IV; angiogenesis; nitric oxide; JAK2/STAT3; ERK1/2 astragaloside IV; angiogenesis; nitric oxide; JAK2/STAT3; ERK1/2
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Wang, S.-G.; Xu, Y.; Chen, J.-D.; Yang, C.-H.; Chen, X.-H. Astragaloside IV Stimulates Angiogenesis and Increases Nitric Oxide Accumulation via JAK2/STAT3 and ERK1/2 Pathway. Molecules 2013, 18, 12809-12819.

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