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Molecules 2013, 18(10), 12621-12632; doi:10.3390/molecules181012621

Assessment of the Anti-Protozoal Activity of Crude Carica papaya Seed Extract against Trypanosoma cruzi

1, 1
1 Laboratorio de Biología Celular, CIR "Dr. Hideyo Noguchi", CA Biomedicina de Enfermedades Infecciosas y Parasitarias, Universidad Autónoma de Yucatán, Ave. Itzaes # 490 x 59, Centro C. P. 97000, Mérida Yucatán, Mexico 2 Departamento de Salud Animal y Medicina Preventiva, CA Salud Animal, Facultad de Medicina Veterinaria y Zootecnia, Universidad Autónoma de Yucatán, Km. 15.5 Carr. Merida-Xmatkuil AP. 4-116 Mérida, Yucatán, Mexico 3 Universidad Autónoma Metropolitana-Xochimilco, Calzada del Hueso # 1100. C.P. 04960, México D.F. A.P. 23–181, Mexico
* Author to whom correspondence should be addressed.
Received: 27 August 2013 / Revised: 20 September 2013 / Accepted: 23 September 2013 / Published: 11 October 2013
(This article belongs to the Special Issue Plant Natural Products against Human Parasites)
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In order to determine the in vivo activity against the protozoan Trypanosoma cruzi, two doses (50 and 75 mg/kg) of a chloroform extract of Carica papaya seeds were evaluated compared with a control group of allopurinol. The activity of a mixture of the three main compounds (oleic, palmitic and stearic acids in a proportion of 45.9% of oleic acid, 24.1% of palmitic and 8.52% of stearic acid previously identified in the crude extract of C. papaya was evaluated at doses of 100, 200 and 300 mg/kg. Both doses of the extracts were orally administered for 28 days. A significant reduction (p < 0.05) in the number of blood trypomastigotes was observed in animals treated with the evaluated doses of the C. papaya extract in comparison with the positive control group (allopurinol 8.5 mg/kg). Parasitemia in animals treated with the fatty acids mixture was also significantly reduced (p < 0.05), compared to negative control animals. These results demonstrate that the fatty acids identified in the seed extracts of C. papaya (from ripe fruit) are able to reduce the number of parasites from both parasite stages, blood trypomastigote and amastigote (intracellular stage).
Keywords: Chagas’ disease; antiprotozoal; fatty acids; in vivo; Carica papaya Chagas’ disease; antiprotozoal; fatty acids; in vivo; Carica papaya
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Jiménez-Coello, M.; Guzman-Marín, E.; Ortega-Pacheco, A.; Perez-Gutiérrez, S.; Acosta-Viana, K.Y. Assessment of the Anti-Protozoal Activity of Crude Carica papaya Seed Extract against Trypanosoma cruzi. Molecules 2013, 18, 12621-12632.

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