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Structural Correlation of Some Heterocyclic Chalcone Analogues and Evaluation of Their Antioxidant Potential
Crystallography Unit, School of Physics, Universiti Sains Malaysia, Penang 11800 USM, Malaysia
Department of Chemistry, Alva's Institute of Engineering & Technology, Mijar, Moodbidri 574225, India
Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia
* Author to whom correspondence should be addressed.
Received: 12 August 2013; in revised form: 14 September 2013 / Accepted: 23 September 2013 / Published: 26 September 2013
Abstract: A series of six novel heterocyclic chalcone analogues 4(a–f) has been synthesized by condensing 2-acetyl-5-chlorothiophene with benzaldehyde derivatives in methanol at room temperature using a catalytic amount of sodium hydroxide. The newly synthesized compounds are characterized by IR, mass spectra, elemental analysis and melting point. Subsequently; the structures of these compounds were determined using single crystal X-ray diffraction. All the synthesized compounds were screened for their antioxidant potential by employing various in vitro models such as DPPH free radical scavenging assay, ABTS radical scavenging assay, ferric reducing antioxidant power and cupric ion reducing antioxidant capacity. Results reflect the structural impact on the antioxidant ability of the compounds. The IC50 values illustrate the mild to good antioxidant activities of the reported compounds. Among them, 4f with a p-methoxy substituent was found to be more potent as antioxidant agent.
Keywords: heterocyclic; radical scavenging; reducing; substituent; overlay
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MDPI and ACS Style
Kumar, C.S.C.; Loh, W.-S.; Ooi, C.W.; Quah, C.K.; Fun, H.-K. Structural Correlation of Some Heterocyclic Chalcone Analogues and Evaluation of Their Antioxidant Potential. Molecules 2013, 18, 11996-12011.
Kumar CSC, Loh W-S, Ooi CW, Quah CK, Fun H-K. Structural Correlation of Some Heterocyclic Chalcone Analogues and Evaluation of Their Antioxidant Potential. Molecules. 2013; 18(10):11996-12011.
Kumar, C. S.C.; Loh, Wan-Sin; Ooi, Chin W.; Quah, Ching K.; Fun, Hoong-Kun. 2013. "Structural Correlation of Some Heterocyclic Chalcone Analogues and Evaluation of Their Antioxidant Potential." Molecules 18, no. 10: 11996-12011.