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Molecules 2013, 18(10), 11978-11995; doi:10.3390/molecules181011978
Article

Synthesis and Antibacterial Evaluation of Some Novel Imidazole and Benzimidazole Sulfonamides

1,* , 1, 1,2,* , 1, 3 and 4
1 Chemistry Department, Faculty of Science, University of Malaya, Kuala Lumpur 50603, Malaysia 2 Section for Co-curricular Courses, External Faculty Electives and TITAS (SKET), University of Malaya, Kuala Lumpur 50603, Malaysia 3 Department of Chemistry, Collage of Science for Women, Baghdad University, Aljadriya 10071, Baghdad, Iraq 4 School of Biosciences and Biotechnology, Faculty of Science and Technology, University Kebangsaan Malaysia, Bangi 43600, Selangor, Malaysia
* Authors to whom correspondence should be addressed.
Received: 6 August 2013 / Revised: 11 September 2013 / Accepted: 12 September 2013 / Published: 26 September 2013
(This article belongs to the Section Organic Synthesis)
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Abstract

Several new substituted sulfonamide compounds were synthesized and their structures were confirmed by 1H-NMR, 13C-NMR, FT-IR, and mass spectroscopy. The antibacterial activities of the synthesized compounds were screened against standard strains of six Gram positive and four Gram negative bacteria using the microbroth dilution assay. Most of the compounds studied showed promising activities against both types of bacteria.
Keywords: sulfonamide; 4-methylbenzenesulfonamide; 4-nitrobenzenesulfonamide; 4-methoxybenzenesulfonamide; imidazole; benzimidazole; antibacterial activity sulfonamide; 4-methylbenzenesulfonamide; 4-nitrobenzenesulfonamide; 4-methoxybenzenesulfonamide; imidazole; benzimidazole; antibacterial activity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Al-Mohammed, N.N.; Alias, Y.; Abdullah, Z.; Shakir, R.M.; Taha, E.M.; Hamid, A.A. Synthesis and Antibacterial Evaluation of Some Novel Imidazole and Benzimidazole Sulfonamides. Molecules 2013, 18, 11978-11995.

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