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Molecules 2013, 18(1), 963-973; doi:10.3390/molecules18010963

Chemical Composition and Antibacterial Activity of Essential Oils from Different Parts of Leonurus japonicus Houtt.

1
State Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources, Sichuan Province and Ministry of Science and Technology, Chengdu 610075, Sichuan, China
2
Pharmacy College, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, Sichuan, China
*
Author to whom correspondence should be addressed.
Received: 10 December 2012 / Revised: 30 December 2012 / Accepted: 4 January 2013 / Published: 14 January 2013
(This article belongs to the Section Natural Products)
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Abstract

The herb and fruits of Leonurus japonicus Houtt., named “Yimucao” and “Chongweizi”, respectively, in Chinese, have been widely used in China as gynecological medicines. The components of the essential oils obtained by hydrodistillation were investigated by GC-MS. The antibacterial activity of the essential oils was determined by micro-dilution assay. The results showed large variations in the chemical composition and antibacterial activity of the oils. The oil of “Yimucao” showed antibacterial activity against various Gram-positive bacteria and consisted mainly of sesquiterpenes and diterpenes, with phytone, phytol, caryophyllene oxide and β-caryophyllene being the most significant constituents, whereas the oil of “Chongweizi”, mainly made up of bornyl acetate and aliphatic hydrocarbons, was inactive in the antibacterial assay. Further study of the main compounds in “Yimucao oil” showed that β-caryophyllene had wide-spectrum activity against Gram-positive bacteria.
Keywords: Leonurus japonicus; essential oil composition; antibacterial activity; β-caryophyllene Leonurus japonicus; essential oil composition; antibacterial activity; β-caryophyllene
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Xiong, L.; Peng, C.; Zhou, Q.-M.; Wan, F.; Xie, X.-F.; Guo, L.; Li, X.-H.; He, C.-J.; Dai, O. Chemical Composition and Antibacterial Activity of Essential Oils from Different Parts of Leonurus japonicus Houtt.. Molecules 2013, 18, 963-973.

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