Molecules 2013, 18(1), 535-544; doi:10.3390/molecules18010535
Article

Enaminonitriles in Heterocyclic Synthesis: A Route to 1,3-Diaryl-4-aminopyrazole Derivatives

1, 1,* email and 2
Received: 29 October 2012; in revised form: 15 November 2012 / Accepted: 24 December 2012 / Published: 2 January 2013
(This article belongs to the Section Theoretical Chemistry)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Benzylcyanide and 4-nitrobenzylcyanide condensed with triethyl orthoformate and piperidine or morpholine to yield 2-aryl-2-piperidinyl or 2-morpholinylacrylonitriles. These coupled with aromatic diazonium salts to yield the 2-arylhydrazno-2-arylethane nitriles in good yields. The latter were converted into 4-aminopyrazoles in good yields using the Thorpe-Ziegler cyclization.
Keywords: enaminonitriles; 4-aminopyrazole; Thorpe-Ziegler cyclization; microwave irradiation
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MDPI and ACS Style

Medrasi, H.Y.; Al-Sheikh, M.A.; Salaheldin, A.M. Enaminonitriles in Heterocyclic Synthesis: A Route to 1,3-Diaryl-4-aminopyrazole Derivatives. Molecules 2013, 18, 535-544.

AMA Style

Medrasi HY, Al-Sheikh MA, Salaheldin AM. Enaminonitriles in Heterocyclic Synthesis: A Route to 1,3-Diaryl-4-aminopyrazole Derivatives. Molecules. 2013; 18(1):535-544.

Chicago/Turabian Style

Medrasi, Hanadi Y.; Al-Sheikh, Mariam A.; Salaheldin, Abdellatif M. 2013. "Enaminonitriles in Heterocyclic Synthesis: A Route to 1,3-Diaryl-4-aminopyrazole Derivatives." Molecules 18, no. 1: 535-544.

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