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Anti-inflammatory Lignans from the Fruits of Acanthopanax sessiliflorus
Herbal Crop Utilization Research Team, National Institute of Horticultural and Herbal Science, RDA, Eumseong 369-873, Korea
Graduate School of Biotechnology and Department of Oriental Medicinal Materials & Processing, Kyung Hee University, Yongin 446-701, Korea
Brewing Research Center, Han Kyung National University, Ansung 456-749, Korea
* Author to whom correspondence should be addressed.
Received: 24 August 2012; in revised form: 10 December 2012 / Accepted: 14 December 2012 / Published: 21 December 2012
Abstract: A new lignan, named acanthosessilin A (1), as well as eight known lignan and lignan glycosides 2-9 were isolated from an ethanolic extract of Acanthopanax sessiliflorus fruits. The chemical structures were determined by spectroscopic methods, including HR-EIMS, 1D NMR (1H, 13C, DEPT), 2D NMR (gCOSY, gHSQC, gHMBC, NOESY), and IR spectroscopy. All isolated compounds were tested for the ability to inhibit LPS-induced nitric oxide production in RAW264.7 macrophages.
Keywords: Acanthopanax sessiliflorus; lignan; acanthosessilin A; nitric oxide
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Lee, D.-Y.; Seo, K.-H.; Jeong, R.-H.; Lee, S.-M.; Kim, G.-S.; Noh, H.-J.; Kim, S.-Y.; Kim, G.-W.; Kim, J.-Y.; Baek, N.-I. Anti-inflammatory Lignans from the Fruits of Acanthopanax sessiliflorus. Molecules 2013, 18, 41-49.
Lee D-Y, Seo K-H, Jeong R-H, Lee S-M, Kim G-S, Noh H-J, Kim S-Y, Kim G-W, Kim J-Y, Baek N-I. Anti-inflammatory Lignans from the Fruits of Acanthopanax sessiliflorus. Molecules. 2013; 18(1):41-49.
Lee, Dae-Young; Seo, Kyeong-Hwa; Jeong, Rak-Hun; Lee, Sang-Min; Kim, Geum-Soog; Noh, Hyung-Jun; Kim, Seung-Yu; Kim, Gye-Won; Kim, Ji-Young; Baek, Nam-In. 2013. "Anti-inflammatory Lignans from the Fruits of Acanthopanax sessiliflorus." Molecules 18, no. 1: 41-49.