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Molecules 2013, 18(1), 41-49; doi:10.3390/molecules18010041
Article

Anti-inflammatory Lignans from the Fruits of Acanthopanax sessiliflorus

1, 2, 2, 2, 1, 1, 1, 3, 2 and 2,*
1 Herbal Crop Utilization Research Team, National Institute of Horticultural and Herbal Science, RDA, Eumseong 369-873, Korea 2 Graduate School of Biotechnology and Department of Oriental Medicinal Materials & Processing, Kyung Hee University, Yongin 446-701, Korea 3 Brewing Research Center, Han Kyung National University, Ansung 456-749, Korea
* Author to whom correspondence should be addressed.
Received: 24 August 2012 / Revised: 10 December 2012 / Accepted: 14 December 2012 / Published: 21 December 2012
(This article belongs to the Section Metabolites)
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Abstract

A new lignan, named acanthosessilin A (1), as well as eight known lignan and lignan glycosides 2-9 were isolated from an ethanolic extract of Acanthopanax sessiliflorus fruits. The chemical structures were determined by spectroscopic methods, including HR-EIMS, 1D NMR (1H, 13C, DEPT), 2D NMR (gCOSY, gHSQC, gHMBC, NOESY), and IR spectroscopy. All isolated compounds were tested for the ability to inhibit LPS-induced nitric oxide production in RAW264.7 macrophages.
Keywords: Acanthopanax sessiliflorus; lignan; acanthosessilin A; nitric oxide Acanthopanax sessiliflorus; lignan; acanthosessilin A; nitric oxide
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Lee, D.-Y.; Seo, K.-H.; Jeong, R.-H.; Lee, S.-M.; Kim, G.-S.; Noh, H.-J.; Kim, S.-Y.; Kim, G.-W.; Kim, J.-Y.; Baek, N.-I. Anti-inflammatory Lignans from the Fruits of Acanthopanax sessiliflorus. Molecules 2013, 18, 41-49.

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