Anti-inflammatory Lignans from the Fruits of Acanthopanax sessiliflorus

doi:10.3390/molecules18010041

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Molecules 2013, 18(1), 41-49; doi:10.3390/molecules18010041

Article

Anti-inflammatory Lignans from the Fruits of Acanthopanax sessiliflorus

Dae-Young Lee¹, Kyeong-Hwa Seo², Rak-Hun Jeong², Sang-Min Lee², Geum-Soog Kim¹, Hyung-Jun Noh¹, Seung-Yu Kim¹, Gye-Won Kim³, Ji-Young Kim² and Nam-In Baek^2,*

¹ Herbal Crop Utilization Research Team, National Institute of Horticultural and Herbal Science, RDA, Eumseong 369-873, Korea ² Graduate School of Biotechnology and Department of Oriental Medicinal Materials & Processing, Kyung Hee University, Yongin 446-701, Korea ³ Brewing Research Center, Han Kyung National University, Ansung 456-749, Korea

* Author to whom correspondence should be addressed.

Received: 24 August 2012; in revised form: 10 December 2012 / Accepted: 14 December 2012 / Published: 21 December 2012

(This article belongs to the Section Natural Products)

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Abstract: A new lignan, named acanthosessilin A (1), as well as eight known lignan and lignan glycosides 2-9 were isolated from an ethanolic extract of Acanthopanax sessiliflorus fruits. The chemical structures were determined by spectroscopic methods, including HR-EIMS, 1D NMR (¹H, ¹³C, DEPT), 2D NMR (gCOSY, gHSQC, gHMBC, NOESY), and IR spectroscopy. All isolated compounds were tested for the ability to inhibit LPS-induced nitric oxide production in RAW264.7 macrophages.

Keywords: Acanthopanax sessiliflorus; lignan; acanthosessilin A; nitric oxide

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Cite This Article

MDPI and ACS Style

Lee, D.-Y.; Seo, K.-H.; Jeong, R.-H.; Lee, S.-M.; Kim, G.-S.; Noh, H.-J.; Kim, S.-Y.; Kim, G.-W.; Kim, J.-Y.; Baek, N.-I. Anti-inflammatory Lignans from the Fruits of Acanthopanax sessiliflorus. Molecules 2013, 18, 41-49.

AMA Style

Lee D-Y, Seo K-H, Jeong R-H, Lee S-M, Kim G-S, Noh H-J, Kim S-Y, Kim G-W, Kim J-Y, Baek N-I. Anti-inflammatory Lignans from the Fruits of Acanthopanax sessiliflorus. Molecules. 2013; 18(1):41-49.

Chicago/Turabian Style

Lee, Dae-Young; Seo, Kyeong-Hwa; Jeong, Rak-Hun; Lee, Sang-Min; Kim, Geum-Soog; Noh, Hyung-Jun; Kim, Seung-Yu; Kim, Gye-Won; Kim, Ji-Young; Baek, Nam-In. 2013. "Anti-inflammatory Lignans from the Fruits of Acanthopanax sessiliflorus." Molecules 18, no. 1: 41-49.

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