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Molecules 2013, 18(1), 204-224; doi:10.3390/molecules18010204

Anti-Infectious Agents against MRSA

 and *
Received: 16 October 2012 / Revised: 3 December 2012 / Accepted: 14 December 2012 / Published: 24 December 2012
(This article belongs to the collection Bioactive Compounds)
Download PDF [770 KB, uploaded 18 June 2014]
Abstract: Clinically useful antibiotics, β-lactams and vancomycin, are known to inhibit bacterial cell wall peptidoglycan synthesis. Methicillin-resistant Staphylococcus aureus (MRSA) has a unique cell wall structure consisting of peptidoglycan and wall teichoic acid. In recent years, new anti-infectious agents (spirohexaline, tripropeptin C, DMPI, CDFI, cyslabdan, 1835F03, and BPH-652) targeting MRSA cell wall biosynthesis have been discovered using unique screening methods. These agents were found to inhibit important enzymes involved in cell wall biosynthesis such as undecaprenyl pyrophosphate (UPP) synthase, FemA, flippase, or UPP phosphatase. In this review, the discovery, the mechanism of action, and the future of these anti-infectious agents are described.
Keywords: MRSA; anti-infectious agents; peptidoglycan; teichoic acid; virulence factors MRSA; anti-infectious agents; peptidoglycan; teichoic acid; virulence factors
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Koyama, N.; Inokoshi, J.; Tomoda, H. Anti-Infectious Agents against MRSA. Molecules 2013, 18, 204-224.

AMA Style

Koyama N, Inokoshi J, Tomoda H. Anti-Infectious Agents against MRSA. Molecules. 2013; 18(1):204-224.

Chicago/Turabian Style

Koyama, Nobuhiro; Inokoshi, Junji; Tomoda, Hiroshi. 2013. "Anti-Infectious Agents against MRSA." Molecules 18, no. 1: 204-224.

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