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Molecules 2012, 17(9), 11010-11025; doi:10.3390/molecules170911010
Article

Novel Coumarin Derivatives Containing 1,2,4-Triazole, 4,5-Dicyanoimidazole and Purine Moieties: Synthesis and Evaluation of Their Cytostatic Activity

1, 1, 1, 2, 2, 2, 2, 1 and 1,*
Received: 16 July 2012; in revised form: 23 August 2012 / Accepted: 3 September 2012 / Published: 12 September 2012
(This article belongs to the Section Medicinal Chemistry)
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Abstract: We report here on the synthesis and in vitro anti-tumor effects of a series of novel 1,2,4-triazole (compounds 36), 4,5-dicyanoimidazole (compound 7), and purine (compounds 813) coumarin derivatives and their acyclic nucleoside analogues 1418. Structures of novel compounds 318 were deduced from their 1H- and 13C-NMR and corresponding mass spectra. Results of anti-proliferative assays performed on a panel of selected human tumor cell lines revealed that compound 6 had moderate cytostatic activity against the HeLa cell line (IC50 = 35 µM), whereas compound 10 showed moderate activity against the HeLa (IC50 = 33 µM), HepG2 (IC50 = 25 µM) and SW620 (IC50 = 35 µM) cell lines. These compounds showed no cytotoxic effects on normal (diploid) human fibroblasts.
Keywords: 1,2,4-triazole; 4,5-dicyanoimidazole and purine coumarin derivatives; acyclic nucleoside analogues; antitumor activity evaluation 1,2,4-triazole; 4,5-dicyanoimidazole and purine coumarin derivatives; acyclic nucleoside analogues; antitumor activity evaluation
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Benci, K.; Mandić, L.; Suhina, T.; Sedić, M.; Klobučar, M.; Kraljević Pavelić, S.; Pavelić, K.; Wittine, K.; Mintas, M. Novel Coumarin Derivatives Containing 1,2,4-Triazole, 4,5-Dicyanoimidazole and Purine Moieties: Synthesis and Evaluation of Their Cytostatic Activity. Molecules 2012, 17, 11010-11025.

AMA Style

Benci K, Mandić L, Suhina T, Sedić M, Klobučar M, Kraljević Pavelić S, Pavelić K, Wittine K, Mintas M. Novel Coumarin Derivatives Containing 1,2,4-Triazole, 4,5-Dicyanoimidazole and Purine Moieties: Synthesis and Evaluation of Their Cytostatic Activity. Molecules. 2012; 17(9):11010-11025.

Chicago/Turabian Style

Benci, Krešimir; Mandić, Leo; Suhina, Tomislav; Sedić, Mirela; Klobučar, Marko; Kraljević Pavelić, Sandra; Pavelić, Krešimir; Wittine, Karlo; Mintas, Mladen. 2012. "Novel Coumarin Derivatives Containing 1,2,4-Triazole, 4,5-Dicyanoimidazole and Purine Moieties: Synthesis and Evaluation of Their Cytostatic Activity." Molecules 17, no. 9: 11010-11025.



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