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Molecules 2012, 17(9), 10503-10539; doi:10.3390/molecules170910503

Promising Therapeutics with Natural Bioactive Compounds for Improving Learning and Memory — A Review of Randomized Trials

1
Department of Biotechnology, Konkuk University, Chungju 380-701, Korea
2
Department of Neurology, School of Medicine, Konkuk University, Chungju 380-704, Korea
*
Author to whom correspondence should be addressed.
Received: 31 July 2012 / Revised: 6 August 2012 / Accepted: 27 August 2012 / Published: 3 September 2012
(This article belongs to the Section Natural Products)
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Abstract

Cognitive disorders can be associated with brain trauma, neurodegenerative disease or as a part of physiological aging. Aging in humans is generally associated with deterioration of cognitive performance and, in particular, learning and memory. Different therapeutic approaches are available to treat cognitive impairment during physiological aging and neurodegenerative or psychiatric disorders. Traditional herbal medicine and numerous plants, either directly as supplements or indirectly in the form of food, improve brain functions including memory and attention. More than a hundred herbal medicinal plants have been traditionally used for learning and memory improvement, but only a few have been tested in randomized clinical trials. Here, we will enumerate those medicinal plants that show positive effects on various cognitive functions in learning and memory clinical trials. Moreover, besides natural products that show promising effects in clinical trials, we briefly discuss medicinal plants that have promising experimental data or initial clinical data and might have potential to reach a clinical trial in the near future.
Keywords: learning and memory; cognition; clinical trials; herbal medicines; panax gingseng; EGb 761; BT-11; GK501; asarone; tofu learning and memory; cognition; clinical trials; herbal medicines; panax gingseng; EGb 761; BT-11; GK501; asarone; tofu
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Kumar, H.; More, S.V.; Han, S.-D.; Choi, J.-Y.; Choi, D.-K. Promising Therapeutics with Natural Bioactive Compounds for Improving Learning and Memory — A Review of Randomized Trials. Molecules 2012, 17, 10503-10539.

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