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Molecules 2012, 17(8), 9413-9420; doi:10.3390/molecules17089413
Article

N-Substituted 5-Chloro-6-phenylpyridazin-3(2H)-ones: Synthesis, Insecticidal Activity Against Plutella xylostella (L.) and SAR Study

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Received: 5 July 2012; in revised form: 27 July 2012 / Accepted: 30 July 2012 / Published: 6 August 2012
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Abstract: A series of N-substituted 5-chloro-6-phenylpyridazin-3(2H)-one derivatives were synthesized based on our previous work; all compounds were characterized by spectral data and tested for in vitro insecticidal activity against Plutella xylostella. The results showed that the synthesized pyridazin-3(2H)-one compounds possessed good insecticidal activities, especially the compounds 4b, 4d, and 4h which showed > 90% activity at 100 mg/L. The structure-activity relationships (SAR) for these compounds were also discussed.
Keywords: pridazin-3(2H)-one; synthesis; insecticidal activity; SAR study; Plutella xylostella pridazin-3(2H)-one; synthesis; insecticidal activity; SAR study; Plutella xylostella
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Wu, J.; Kang, S.; Yuan, Q.; Luo, L.; Ma, J.; Shi, Q.; Yang, S. N-Substituted 5-Chloro-6-phenylpyridazin-3(2H)-ones: Synthesis, Insecticidal Activity Against Plutella xylostella (L.) and SAR Study. Molecules 2012, 17, 9413-9420.

AMA Style

Wu J, Kang S, Yuan Q, Luo L, Ma J, Shi Q, Yang S. N-Substituted 5-Chloro-6-phenylpyridazin-3(2H)-ones: Synthesis, Insecticidal Activity Against Plutella xylostella (L.) and SAR Study. Molecules. 2012; 17(8):9413-9420.

Chicago/Turabian Style

Wu, Jian; Kang, Shenghong; Yuan, Qinkun; Luo, Lijun; Ma, Juan; Shi, Qingcai; Yang, Song. 2012. "N-Substituted 5-Chloro-6-phenylpyridazin-3(2H)-ones: Synthesis, Insecticidal Activity Against Plutella xylostella (L.) and SAR Study." Molecules 17, no. 8: 9413-9420.


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