Molecules 2012, 17(8), 9413-9420; doi:10.3390/molecules17089413
Article

N-Substituted 5-Chloro-6-phenylpyridazin-3(2H)-ones: Synthesis, Insecticidal Activity Against Plutella xylostella (L.) and SAR Study

Jian Wu* email, Shenghong Kangemail, Qinkun Yuanemail, Lijun Luoemail, Juan Maemail, Qingcai Shiemail and Song Yangemail
State Key Laboratory Breeding Base of Green Pesticides and Agricultural Bioengineering, Key Laboratory of Green Pesticides and Agricultural Bioengineering, Ministry of Education, Guizhou University, Guiyang 550025, China
* Author to whom correspondence should be addressed.
Received: 5 July 2012; in revised form: 27 July 2012 / Accepted: 30 July 2012 / Published: 6 August 2012
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Abstract: A series of N-substituted 5-chloro-6-phenylpyridazin-3(2H)-one derivatives were synthesized based on our previous work; all compounds were characterized by spectral data and tested for in vitro insecticidal activity against Plutella xylostella. The results showed that the synthesized pyridazin-3(2H)-one compounds possessed good insecticidal activities, especially the compounds 4b, 4d, and 4h which showed > 90% activity at 100 mg/L. The structure-activity relationships (SAR) for these compounds were also discussed.
Keywords: pridazin-3(2H)-one; synthesis; insecticidal activity; SAR study; Plutella xylostella

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Cite This Article

MDPI and ACS Style

Wu, J.; Kang, S.; Yuan, Q.; Luo, L.; Ma, J.; Shi, Q.; Yang, S. N-Substituted 5-Chloro-6-phenylpyridazin-3(2H)-ones: Synthesis, Insecticidal Activity Against Plutella xylostella (L.) and SAR Study. Molecules 2012, 17, 9413-9420.

AMA Style

Wu J, Kang S, Yuan Q, Luo L, Ma J, Shi Q, Yang S. N-Substituted 5-Chloro-6-phenylpyridazin-3(2H)-ones: Synthesis, Insecticidal Activity Against Plutella xylostella (L.) and SAR Study. Molecules. 2012; 17(8):9413-9420.

Chicago/Turabian Style

Wu, Jian; Kang, Shenghong; Yuan, Qinkun; Luo, Lijun; Ma, Juan; Shi, Qingcai; Yang, Song. 2012. "N-Substituted 5-Chloro-6-phenylpyridazin-3(2H)-ones: Synthesis, Insecticidal Activity Against Plutella xylostella (L.) and SAR Study." Molecules 17, no. 8: 9413-9420.

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