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Molecules 2012, 17(8), 9413-9420; doi:10.3390/molecules17089413
Article

N-Substituted 5-Chloro-6-phenylpyridazin-3(2H)-ones: Synthesis, Insecticidal Activity Against Plutella xylostella (L.) and SAR Study

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State Key Laboratory Breeding Base of Green Pesticides and Agricultural Bioengineering, Key Laboratory of Green Pesticides and Agricultural Bioengineering, Ministry of Education, Guizhou University, Guiyang 550025, China
* Author to whom correspondence should be addressed.
Received: 5 July 2012 / Revised: 27 July 2012 / Accepted: 30 July 2012 / Published: 6 August 2012
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Abstract

A series of N-substituted 5-chloro-6-phenylpyridazin-3(2H)-one derivatives were synthesized based on our previous work; all compounds were characterized by spectral data and tested for in vitro insecticidal activity against Plutella xylostella. The results showed that the synthesized pyridazin-3(2H)-one compounds possessed good insecticidal activities, especially the compounds 4b, 4d, and 4h which showed > 90% activity at 100 mg/L. The structure-activity relationships (SAR) for these compounds were also discussed.
Keywords: pridazin-3(2H)-one; synthesis; insecticidal activity; SAR study; Plutella xylostella pridazin-3(2H)-one; synthesis; insecticidal activity; SAR study; Plutella xylostella
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Wu, J.; Kang, S.; Yuan, Q.; Luo, L.; Ma, J.; Shi, Q.; Yang, S. N-Substituted 5-Chloro-6-phenylpyridazin-3(2H)-ones: Synthesis, Insecticidal Activity Against Plutella xylostella (L.) and SAR Study. Molecules 2012, 17, 9413-9420.

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