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Molecules 2012, 17(8), 9104-9115; doi:10.3390/molecules17089104

Ursolic Acid Inhibits Cigarette Smoke Extract-Induced Human Bronchial Epithelial Cell Injury and Prevents Development of Lung Cancer

1
Key Laboratory of Delivery Systems of Chinese Meteria Medica, Jiangsu Provincial Academy of Chinese Medicine, Nanjing, Jiangsu 210028, China
2
Department of Life Sciences, Anhui University, Hefei, Anhui 230039, China
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 8 June 2012 / Revised: 25 July 2012 / Accepted: 26 July 2012 / Published: 2 August 2012
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Abstract

Cigarette smoking is the main cause of chronic obstructive pulmonary disease and lung cancer. The present study was aimed to explore the chemopreventive effect of ursolic acid (UA) on these diseases. In the CSE treated normal human bronchial epithelial cell model, UA alleviated cytotoxicity caused by CSE, recovered the intracellular redox balance, and relieved the stimulation of external deleterious factors as well. UA mitigated CSE-induced DNA damage through the Nrf2 (nuclear factor erythroid 2-related factor 2) pathway. Moreover, UA inhibited lung cancer development in the model established by A549 cells in nude mice in vivo. For the first time, our results indicate that UA could be developed as a potential lung cancer chemopreventive agent.
Keywords: Nrf2; CSE; phase II detoxifying enzymes; ursolic acid; chemopreventive Nrf2; CSE; phase II detoxifying enzymes; ursolic acid; chemopreventive
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Liu, W.; Tan, X.; Shu, L.; Sun, H.; Song, J.; Jin, P.; Yu, S.; Sun, M.; Jia, X. Ursolic Acid Inhibits Cigarette Smoke Extract-Induced Human Bronchial Epithelial Cell Injury and Prevents Development of Lung Cancer. Molecules 2012, 17, 9104-9115.

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