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Molecules 2012, 17(8), 9070-9080; doi:10.3390/molecules17089070

Evaluation of the Pharmacological Function of Ulinastatin in Experimental Animals

1
Department of Cardiac Surgery, Provincial Hospital Affiliated to Shandong University, 324# Jingwu-Weiqi Road, Jinan, 250021, China
2
Department of Anesthesia, Provincial Hospital Affiliated to Shandong University, 324# Jingwu-Weiqi Road, Jinan, 250021, China
3
Department of Cardiology, Provincial Hospital Affiliated to Shandong University, 324# Jingwu-Weiqi Road, Jinan, 250021, China
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 2 July 2012 / Revised: 21 July 2012 / Accepted: 21 July 2012 / Published: 31 July 2012
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Abstract

Organ protection is a routine therapy in severe injuries. Our aim was to evaluate the beneficial effects of ulinastatin in experimental rats. Rats were randomly divided into a sham control, a model control and an ulinastatin-treated group. Malondialdehyde (MDA) and superoxide dismutase (SOD) levels were determined. Serum amylase, serum aspartate aminotransaminase (AST), lactate dehydrogenase (LDH) and creatine kinase isoenzyme (CKMD) activities, interleukin-8 (IL-8), tumor necrosis factor-α (TNF-α), nitric oxide (NO) and cardiac troponin I (nTnl) levels were examined. Results showed that ulinastatin decreased MDA levels and ameliorated the down-regulation of SOD activity. In addition, ulinastatin pretreatment may decrease serum AST, LDH and CKMD activities, IL-8, TNF-α, and nTnl levels, and enhance NO level. Our results demonstrated that oxidative injury occurred after IR and that ulinastatin exhibits significant protective effects against these effects.
Keywords: oxidative injury; SOD; ulinastatin; AST; LDH; NO oxidative injury; SOD; ulinastatin; AST; LDH; NO
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Xu, C.-E.; Zhang, M.-Y.; Zou, C.-W.; Guo, L. Evaluation of the Pharmacological Function of Ulinastatin in Experimental Animals. Molecules 2012, 17, 9070-9080.

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