Next Article in Journal
Effects of Vitamin D Treatment on Skeletal Muscle Histology and Ultrastructural Changes in a Rodent Model
Previous Article in Journal
Synthesis and Characterization of Cationic Glycidyl-Based Poly(aminoester)-Folic Acid Targeting Conjugates and Study on Gene Delivery
Molecules 2012, 17(8), 9070-9080; doi:10.3390/molecules17089070
Article

Evaluation of the Pharmacological Function of Ulinastatin in Experimental Animals

1,†, 2,†, 1 and 3,*
1 Department of Cardiac Surgery, Provincial Hospital Affiliated to Shandong University, 324# Jingwu-Weiqi Road, Jinan, 250021, China 2 Department of Anesthesia, Provincial Hospital Affiliated to Shandong University, 324# Jingwu-Weiqi Road, Jinan, 250021, China 3 Department of Cardiology, Provincial Hospital Affiliated to Shandong University, 324# Jingwu-Weiqi Road, Jinan, 250021, China These authors contributed equally to this work.
* Author to whom correspondence should be addressed.
Received: 2 July 2012 / Revised: 21 July 2012 / Accepted: 21 July 2012 / Published: 31 July 2012
View Full-Text   |   Download PDF [406 KB, uploaded 18 June 2014]   |   Browse Figures

Abstract

Organ protection is a routine therapy in severe injuries. Our aim was to evaluate the beneficial effects of ulinastatin in experimental rats. Rats were randomly divided into a sham control, a model control and an ulinastatin-treated group. Malondialdehyde (MDA) and superoxide dismutase (SOD) levels were determined. Serum amylase, serum aspartate aminotransaminase (AST), lactate dehydrogenase (LDH) and creatine kinase isoenzyme (CKMD) activities, interleukin-8 (IL-8), tumor necrosis factor-α (TNF-α), nitric oxide (NO) and cardiac troponin I (nTnl) levels were examined. Results showed that ulinastatin decreased MDA levels and ameliorated the down-regulation of SOD activity. In addition, ulinastatin pretreatment may decrease serum AST, LDH and CKMD activities, IL-8, TNF-α, and nTnl levels, and enhance NO level. Our results demonstrated that oxidative injury occurred after IR and that ulinastatin exhibits significant protective effects against these effects.
Keywords: oxidative injury; SOD; ulinastatin; AST; LDH; NO oxidative injury; SOD; ulinastatin; AST; LDH; NO
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Export to BibTeX |
EndNote


MDPI and ACS Style

Xu, C.-E.; Zhang, M.-Y.; Zou, C.-W.; Guo, L. Evaluation of the Pharmacological Function of Ulinastatin in Experimental Animals. Molecules 2012, 17, 9070-9080.

View more citation formats

Related Articles

Article Metrics

Comments

Citing Articles

[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert