Molecules 2012, 17(8), 8762-8772; doi:10.3390/molecules17088762
Article

Synthesis and Cytotoxicity Testing of New Amido-Substituted Triazolopyrrolo[2,1-c][1,4]benzodiazepine (PBDT) Derivatives

Kumaraswamy Sorra 1,2,† , Chi-Fen Chang 3,† email, Srinivas Pusuluri 1 email, Khagga Mukkanti 2 , Min-Chiau Laiu 4 email, Bo-Ying Bao 5 email, Chia-Hao Su 4,* email and Ta-Hsien Chuang 5,* email
1 Medicinal Chemistry Laboratory, GVK Biosciences Private Limited, Plot No. 5C, IDA Uppal, Hyderabad 500039, AP, India 2 Chemistry Division, Institute of Science and Technology, JNT University, Kukatpally, Hyderabad 500072, AP, India 3 Department of Anatomy and Cell Biology, College of Medicine, National Taiwan University, 1-1, Jen-Ai Road, Taipei 100, Taiwan 4 Center for Translational Research in Biomedical Sciences, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 833, Taiwan 5 School of Pharmacy, China Medical University, Taichung 40402, Taiwan † These authors contributed equally to this work.
* Authors to whom correspondence should be addressed.
Received: 1 June 2012; in revised form: 16 July 2012 / Accepted: 18 July 2012 / Published: 25 July 2012
(This article belongs to the Section Medicinal Chemistry)
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Abstract: A series of amido-substituted triazolopyrrolo[2,1-c][1,4]benzodiazepine (PBDT) derivatives was synthesized from isatoic anhydride, and their cytotoxicity against the MRC-5 and Mahlavu cell lines was evaluated. The results suggest that compound PBDT-7i with the meta-trifluoromethylbenzoyl substituent can selectively inhibit the growth of Mahlavu cells and has low toxicity towards MRC-5 cells.
Keywords: triazolopyrrolobenzodiazepine; Lawesson’s reagent; cytotoxicity; Mahlavu celles; MRC-5 cells

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MDPI and ACS Style

Sorra, K.; Chang, C.-F.; Pusuluri, S.; Mukkanti, K.; Laiu, M.-C.; Bao, B.-Y.; Su, C.-H.; Chuang, T.-H. Synthesis and Cytotoxicity Testing of New Amido-Substituted Triazolopyrrolo[2,1-c][1,4]benzodiazepine (PBDT) Derivatives. Molecules 2012, 17, 8762-8772.

AMA Style

Sorra K, Chang C-F, Pusuluri S, Mukkanti K, Laiu M-C, Bao B-Y, Su C-H, Chuang T-H. Synthesis and Cytotoxicity Testing of New Amido-Substituted Triazolopyrrolo[2,1-c][1,4]benzodiazepine (PBDT) Derivatives. Molecules. 2012; 17(8):8762-8772.

Chicago/Turabian Style

Sorra, Kumaraswamy; Chang, Chi-Fen; Pusuluri, Srinivas; Mukkanti, Khagga; Laiu, Min-Chiau; Bao, Bo-Ying; Su, Chia-Hao; Chuang, Ta-Hsien. 2012. "Synthesis and Cytotoxicity Testing of New Amido-Substituted Triazolopyrrolo[2,1-c][1,4]benzodiazepine (PBDT) Derivatives." Molecules 17, no. 8: 8762-8772.

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