Molecules 2012, 17(8), 8762-8772; doi:10.3390/molecules17088762
Article

Synthesis and Cytotoxicity Testing of New Amido-Substituted Triazolopyrrolo[2,1-c][1,4]benzodiazepine (PBDT) Derivatives

1,2,†, 3,†email, 1email, 2, 4email, 5email, 4,* email and 5,* email
Received: 1 June 2012; in revised form: 16 July 2012 / Accepted: 18 July 2012 / Published: 25 July 2012
(This article belongs to the Section Medicinal Chemistry)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: A series of amido-substituted triazolopyrrolo[2,1-c][1,4]benzodiazepine (PBDT) derivatives was synthesized from isatoic anhydride, and their cytotoxicity against the MRC-5 and Mahlavu cell lines was evaluated. The results suggest that compound PBDT-7i with the meta-trifluoromethylbenzoyl substituent can selectively inhibit the growth of Mahlavu cells and has low toxicity towards MRC-5 cells.
Keywords: triazolopyrrolobenzodiazepine; Lawesson’s reagent; cytotoxicity; Mahlavu celles; MRC-5 cells
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MDPI and ACS Style

Sorra, K.; Chang, C.-F.; Pusuluri, S.; Mukkanti, K.; Laiu, M.-C.; Bao, B.-Y.; Su, C.-H.; Chuang, T.-H. Synthesis and Cytotoxicity Testing of New Amido-Substituted Triazolopyrrolo[2,1-c][1,4]benzodiazepine (PBDT) Derivatives. Molecules 2012, 17, 8762-8772.

AMA Style

Sorra K, Chang C-F, Pusuluri S, Mukkanti K, Laiu M-C, Bao B-Y, Su C-H, Chuang T-H. Synthesis and Cytotoxicity Testing of New Amido-Substituted Triazolopyrrolo[2,1-c][1,4]benzodiazepine (PBDT) Derivatives. Molecules. 2012; 17(8):8762-8772.

Chicago/Turabian Style

Sorra, Kumaraswamy; Chang, Chi-Fen; Pusuluri, Srinivas; Mukkanti, Khagga; Laiu, Min-Chiau; Bao, Bo-Ying; Su, Chia-Hao; Chuang, Ta-Hsien. 2012. "Synthesis and Cytotoxicity Testing of New Amido-Substituted Triazolopyrrolo[2,1-c][1,4]benzodiazepine (PBDT) Derivatives." Molecules 17, no. 8: 8762-8772.

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