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Molecules 2012, 17(8), 8762-8772; doi:10.3390/molecules17088762
Article

Synthesis and Cytotoxicity Testing of New Amido-Substituted Triazolopyrrolo[2,1-c][1,4]benzodiazepine (PBDT) Derivatives

1,2,†, 3,†
,
1
,
2, 4
,
5
,
4,*  and 5,*
1 Medicinal Chemistry Laboratory, GVK Biosciences Private Limited, Plot No. 5C, IDA Uppal, Hyderabad 500039, AP, India 2 Chemistry Division, Institute of Science and Technology, JNT University, Kukatpally, Hyderabad 500072, AP, India 3 Department of Anatomy and Cell Biology, College of Medicine, National Taiwan University, 1-1, Jen-Ai Road, Taipei 100, Taiwan 4 Center for Translational Research in Biomedical Sciences, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 833, Taiwan 5 School of Pharmacy, China Medical University, Taichung 40402, Taiwan These authors contributed equally to this work.
* Authors to whom correspondence should be addressed.
Received: 1 June 2012 / Revised: 16 July 2012 / Accepted: 18 July 2012 / Published: 25 July 2012
(This article belongs to the Section Medicinal Chemistry)
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Abstract

A series of amido-substituted triazolopyrrolo[2,1-c][1,4]benzodiazepine (PBDT) derivatives was synthesized from isatoic anhydride, and their cytotoxicity against the MRC-5 and Mahlavu cell lines was evaluated. The results suggest that compound PBDT-7i with the meta-trifluoromethylbenzoyl substituent can selectively inhibit the growth of Mahlavu cells and has low toxicity towards MRC-5 cells.
Keywords: triazolopyrrolobenzodiazepine; Lawesson’s reagent; cytotoxicity; Mahlavu celles; MRC-5 cells triazolopyrrolobenzodiazepine; Lawesson’s reagent; cytotoxicity; Mahlavu celles; MRC-5 cells
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Sorra, K.; Chang, C.-F.; Pusuluri, S.; Mukkanti, K.; Laiu, M.-C.; Bao, B.-Y.; Su, C.-H.; Chuang, T.-H. Synthesis and Cytotoxicity Testing of New Amido-Substituted Triazolopyrrolo[2,1-c][1,4]benzodiazepine (PBDT) Derivatives. Molecules 2012, 17, 8762-8772.

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