Molecules 2012, 17(7), 8595-8603; doi:10.3390/molecules17078595
Article

Effect of β-Carotene on Immunity Function and Tumour Growth in Hepatocellular Carcinoma Rats

Department of Hepatobiliary Oncology, Cancer Center, Sun Yat-sen University, 651 Dongfeng East Road, Guangzhou 510060, Guangdong, China These authors contributed equally to this work.
* Author to whom correspondence should be addressed.
Received: 15 May 2012; in revised form: 26 June 2012 / Accepted: 5 July 2012 / Published: 18 July 2012
PDF Full-text Download PDF Full-Text [392 KB, uploaded 18 July 2012 08:16 CEST]
Abstract: The aim of the present study was to investigate the anticancer and immunity activity of β-carotene in hepatocellular carcinoma (HCC) rats. Three days after transplantation, forty Wistar rats were randomly divided into four groups, each group consisting of 10 animals. These groups were control group (untreated), low-dose β-carotene-treated group (20 mg/kg), middle-dose group (40 mg/kg) and high-dose (60 mg/kg) group. β-Carotene-treated groups were fed with β-carotene (20, 40, 60 mg/kg b.w.) orally for 30 days. Control group was treated with the same volume of physiological saline. Another ten rats were served as the normal group. Results showed that 30 days of β-carotene treatment could significantly inhibit tumour growth, enhance blood NK, IL-2, TNF-α, WBC, TP, ALB and A/G levels, and decrease blood ALT, AST and ALP activities in HCC rats. Pathological analysis of liver tissue showed that β-carotene treatment may decrease damage of liver tissue in HCC rats. It can be concluded that β-carotene may improve the immunity function and inhibit tumour growth in HCC rats.
Keywords: β-carotene; immunity function; extraction; ALT; AST

Article Statistics

Load and display the download statistics.

Citations to this Article

Cite This Article

MDPI and ACS Style

Cui, B.; Liu, S.; Wang, Q.; Lin, X. Effect of β-Carotene on Immunity Function and Tumour Growth in Hepatocellular Carcinoma Rats. Molecules 2012, 17, 8595-8603.

AMA Style

Cui B, Liu S, Wang Q, Lin X. Effect of β-Carotene on Immunity Function and Tumour Growth in Hepatocellular Carcinoma Rats. Molecules. 2012; 17(7):8595-8603.

Chicago/Turabian Style

Cui, Bokang; Liu, Su; Wang, Qibo; Lin, Xiaojun. 2012. "Effect of β-Carotene on Immunity Function and Tumour Growth in Hepatocellular Carcinoma Rats." Molecules 17, no. 7: 8595-8603.

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert