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Molecules 2012, 17(7), 8464-8470; doi:10.3390/molecules17078464
Article

Enzymatic Reduction of 9-Methoxytariacuripyrone by Saccharomyces cerevisiae and Its Antimycobacterial Activity

1,2, 3, 3, 4 and 1,*
Received: 11 May 2012 / Revised: 5 July 2012 / Accepted: 5 July 2012 / Published: 12 July 2012
(This article belongs to the Section Metabolites)
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Abstract

Biotransformation processes have been successfully utilized to obtain products of pharmaceutical, chemical, food, and agricultural interest, which are difficult to obtain by classic chemical methods. The compound with antituberculous activity, 9-methoxy-tariacuripyrone (1), isolated from Aristolochia brevipes, was submitted to biotransformation with the yeast Saccharomyces cerevisiae under culture, yielding 5-amino-9-methoxy-3,4-dihydro-2H-benzo[h]chromen-2-one (2). The structure of 2 was elucidated on the basis of spectroscopic analyses. The results mainly show the reduction of the double bond and the nitro group of compound 1. Metabolite 2 demonstrated an increase in anti-tuberculous activity (MIC = 3.12 µg/mL) against the drug-sensitive Mycobacterium tuberculosis (H37Rv) strain, with respect to that shown by 1.
Keywords: biotransformation; Saccharomyces cerevisiae; 9-methoxytariacuripyrone; antituberculous activity biotransformation; Saccharomyces cerevisiae; 9-methoxytariacuripyrone; antituberculous activity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Alvarez-Fitz, P.; Alvarez, L.; Marquina, S.; Luna-Herrera, J.; Navarro-García, V.M. Enzymatic Reduction of 9-Methoxytariacuripyrone by Saccharomyces cerevisiae and Its Antimycobacterial Activity. Molecules 2012, 17, 8464-8470.

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