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Molecules 2012, 17(7), 8471-8482; doi:10.3390/molecules17078471
Article

Antimycobacterial Activity of Constituents from Foeniculum vulgare Var. Dulce Grown in Mexico

1, 1, 2, 2, 3 and 1,*
Received: 21 May 2012; in revised form: 19 June 2012 / Accepted: 19 June 2012 / Published: 13 July 2012
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Abstract: Bioassay guided fractionation of an antimycobacterial extract of Foeniculum vulgare var dulce (Apiaceae) led to the isolation and characterization of 5-hydroxyfurano-coumarin. The chemical structure of this compound was elucidated by 1H and 13C (1D and 2D) Nuclear Magnetic Resonance (NMR) spectroscopy. In addition, the active fractions were analyzed by GC-MS and seventy eight compounds were identified; the major compounds were 1,3-benzenediol, 1-methoxycyclohexene, o-cymene, sorbic acid, 2-hydroxy-3-methyl-2-cyclopenten-1-one, estragole, limonene-10-ol and 3-methyl-2-cyclopenten-1-one. Twenty compounds identified in the active fractions were tested against one sensitive and three MDR strains of Mycobacterium tuberculosis using the Alamar Blue microassay. Compounds that showed some degree of antimycobacterial activity against all strains tested were the following: linoleic acid (MIC 100 µg/mL), oleic acid (MIC 100 µg/mL), 1,3-benzenediol (MIC 100–200 µg/mL), undecanal (MIC 50–200 µg/mL), and 2,4-undecadienal (MIC 25–50 µg/mL), the last being the most active compound. To our knowledge, this is the first report of the presence of 5-hydroxy-furanocoumarin in F. vulgare.
Keywords: Foeniculum vulgare (F. vulgare); Mycobacterium tuberculosis; multidrug resistant (MDR); 5-hydroxyfuranocoumarin Foeniculum vulgare (F. vulgare); Mycobacterium tuberculosis; multidrug resistant (MDR); 5-hydroxyfuranocoumarin
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Esquivel-Ferriño, P.C.; Favela-Hernández, J.M.J.; Garza-González, E.; Waksman, N.; Ríos, M.Y.; Camacho-Corona, M.R. Antimycobacterial Activity of Constituents from Foeniculum vulgare Var. Dulce Grown in Mexico. Molecules 2012, 17, 8471-8482.

AMA Style

Esquivel-Ferriño PC, Favela-Hernández JMJ, Garza-González E, Waksman N, Ríos MY, Camacho-Corona MR. Antimycobacterial Activity of Constituents from Foeniculum vulgare Var. Dulce Grown in Mexico. Molecules. 2012; 17(7):8471-8482.

Chicago/Turabian Style

Esquivel-Ferriño, Patricia C.; Favela-Hernández, Juan Manuel J.; Garza-González, Elvira; Waksman, Noemí; Ríos, María Yolanda; Camacho-Corona, María del Rayo. 2012. "Antimycobacterial Activity of Constituents from Foeniculum vulgare Var. Dulce Grown in Mexico." Molecules 17, no. 7: 8471-8482.



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