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Molecules 2012, 17(7), 8471-8482; doi:10.3390/molecules17078471

Antimycobacterial Activity of Constituents from Foeniculum vulgare Var. Dulce Grown in Mexico

Facultad de Ciencias Químicas, Universidad Autónoma de Nuevo León. Av. Universidad s/n, Ciudad Universitaria, San Nicolás de los Garza, Nuevo León, C.P. 66451, Mexico
Facultad de Medicina, Universidad Autónoma de Nuevo León. Madero y Aguirre Pequeño, Mitras Centro, Monterrey, Nuevo León, C.P. 64460, Mexico
Centro de Investigaciones Químicas, Universidad Autónoma del Estado de Morelos. Av. Universidad 1001, Col. Chamilpa, Cuernavaca, Morelos, C.P. 62209, Mexico
Author to whom correspondence should be addressed.
Received: 21 May 2012 / Revised: 19 June 2012 / Accepted: 19 June 2012 / Published: 13 July 2012
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Bioassay guided fractionation of an antimycobacterial extract of Foeniculum vulgare var dulce (Apiaceae) led to the isolation and characterization of 5-hydroxyfurano-coumarin. The chemical structure of this compound was elucidated by 1H and 13C (1D and 2D) Nuclear Magnetic Resonance (NMR) spectroscopy. In addition, the active fractions were analyzed by GC-MS and seventy eight compounds were identified; the major compounds were 1,3-benzenediol, 1-methoxycyclohexene, o-cymene, sorbic acid, 2-hydroxy-3-methyl-2-cyclopenten-1-one, estragole, limonene-10-ol and 3-methyl-2-cyclopenten-1-one. Twenty compounds identified in the active fractions were tested against one sensitive and three MDR strains of Mycobacterium tuberculosis using the Alamar Blue microassay. Compounds that showed some degree of antimycobacterial activity against all strains tested were the following: linoleic acid (MIC 100 µg/mL), oleic acid (MIC 100 µg/mL), 1,3-benzenediol (MIC 100–200 µg/mL), undecanal (MIC 50–200 µg/mL), and 2,4-undecadienal (MIC 25–50 µg/mL), the last being the most active compound. To our knowledge, this is the first report of the presence of 5-hydroxy-furanocoumarin in F. vulgare.
Keywords: Foeniculum vulgare (F. vulgare); Mycobacterium tuberculosis; multidrug resistant (MDR); 5-hydroxyfuranocoumarin Foeniculum vulgare (F. vulgare); Mycobacterium tuberculosis; multidrug resistant (MDR); 5-hydroxyfuranocoumarin
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Esquivel-Ferriño, P.C.; Favela-Hernández, J.M.J.; Garza-González, E.; Waksman, N.; Ríos, M.Y.; Camacho-Corona, M.R. Antimycobacterial Activity of Constituents from Foeniculum vulgare Var. Dulce Grown in Mexico. Molecules 2012, 17, 8471-8482.

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