Molecules 2012, 17(7), 8419-8429; doi:10.3390/molecules17078419
Article

Evaluation of Antioxidant and Immunity-Enhancing Activities of Sargassum pallidum Aqueous Extract in Gastric Cancer Rats

1email, 2,* email, 1email and 1email
Received: 23 May 2012; in revised form: 28 June 2012 / Accepted: 29 June 2012 / Published: 11 July 2012
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: The effect of Sargassum pallidum (brown seaweed) aqueous extract on the immunity function and antioxidant activities in was studied gastric cancer rats. Treatment with Sargassum pallidum aqueous extract at oral doses 400, 600 or 800 mg/kg body weight was found to provide a dose-dependent protection against N-methyl-N′-nitro-N-nitrosoguanidine (MNNG)-induced immunity damage and oxidative injury by enhancing serum interleukin-2 (IL-2), interleukin-4 (IL-4), interleukin-10 (IL-10) levels, decreasing interleukin-6 (IL-6), interleukin-1β (IL-1β), tumor necrosis factor-alpha (TNF-α) levels, preserving normal antioxidant enzymes activities, and by inhibiting lipid peroxidation in gastric mucosa. It can be concluded that Sargassum pallidum aqueous extract may enhance the immunity and antioxidant activities in gastric cancer rats.
Keywords: Sargassum pallidum aqueous extract; IL-2; IL-4; TNF-α; antioxidant
PDF Full-text Download PDF Full-Text [202 KB, uploaded 18 June 2014 19:50 CEST]

Export to BibTeX |
EndNote


MDPI and ACS Style

Zhang, R.-L.; Luo, W.-D.; Bi, T.-N.; Zhou, S.-K. Evaluation of Antioxidant and Immunity-Enhancing Activities of Sargassum pallidum Aqueous Extract in Gastric Cancer Rats. Molecules 2012, 17, 8419-8429.

AMA Style

Zhang R-L, Luo W-D, Bi T-N, Zhou S-K. Evaluation of Antioxidant and Immunity-Enhancing Activities of Sargassum pallidum Aqueous Extract in Gastric Cancer Rats. Molecules. 2012; 17(7):8419-8429.

Chicago/Turabian Style

Zhang, Rui-Li; Luo, Wen-Da; Bi, Tie-Nan; Zhou, Shen-Kang. 2012. "Evaluation of Antioxidant and Immunity-Enhancing Activities of Sargassum pallidum Aqueous Extract in Gastric Cancer Rats." Molecules 17, no. 7: 8419-8429.

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert