Molecules 2012, 17(7), 7737-7757; doi:10.3390/molecules17077737
Article

New Quinoxaline Derivatives as Potential MT1 and MT2 Receptor Ligands

Saioa Ancizu 1 email, Nerea Castrillo 1 email, Silvia Pérez-Silanes 1 email, Ignacio Aldana 1 email, Antonio Monge 1 email, Philippe Delagrange 2 email, Daniel-Henry Caignard 2 email and Silvia Galiano 1,* email
1 Unidad en Investigación y Desarrollo de Medicamentos, Centro de Investigación en Farmacobiología Aplicada (CIFA), Universidad de Navarra, C/Irunlarrea, 1, 31008 Pamplona, Spain 2 IdRServier, 125 Chemin de ronde, 78290 Croissy-sur-Seine, France
* Author to whom correspondence should be addressed.
Received: 17 April 2012; in revised form: 14 June 2012 / Accepted: 18 June 2012 / Published: 25 June 2012
PDF Full-text Download PDF Full-Text [500 KB, uploaded 25 June 2012 13:32 CEST]
Abstract: Ever since the idea arose that melatonin might promote sleep and resynchronize circadian rhythms, many research groups have centered their efforts on obtaining new melatonin receptor ligands whose pharmacophores include an aliphatic chain of variable length united to an N-alkylamide and a methoxy group (or a bioisostere), linked to a central ring. Substitution of the indole ring found in melatonin with a naphthalene or quinoline ring leads to compounds of similar affinity. The next step in this structural approximation is to introduce a quinoxaline ring (a bioisostere of the quinoline and naphthalene rings) as the central nucleus of future melatoninergic ligands.
Keywords: sleep disorders; melatonin; MT1/MT2 receptors; quinoxalinamide; quinoxalinurea

Article Statistics

Click here to load and display the download statistics.

Cite This Article

MDPI and ACS Style

Ancizu, S.; Castrillo, N.; Pérez-Silanes, S.; Aldana, I.; Monge, A.; Delagrange, P.; Caignard, D.-H.; Galiano, S. New Quinoxaline Derivatives as Potential MT1 and MT2 Receptor Ligands. Molecules 2012, 17, 7737-7757.

AMA Style

Ancizu S, Castrillo N, Pérez-Silanes S, Aldana I, Monge A, Delagrange P, Caignard D-H, Galiano S. New Quinoxaline Derivatives as Potential MT1 and MT2 Receptor Ligands. Molecules. 2012; 17(7):7737-7757.

Chicago/Turabian Style

Ancizu, Saioa; Castrillo, Nerea; Pérez-Silanes, Silvia; Aldana, Ignacio; Monge, Antonio; Delagrange, Philippe; Caignard, Daniel-Henry; Galiano, Silvia. 2012. "New Quinoxaline Derivatives as Potential MT1 and MT2 Receptor Ligands." Molecules 17, no. 7: 7737-7757.

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert