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Molecules 2012, 17(7), 7737-7757; doi:10.3390/molecules17077737
Article

New Quinoxaline Derivatives as Potential MT1 and MT2 Receptor Ligands

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Received: 17 April 2012; in revised form: 14 June 2012 / Accepted: 18 June 2012 / Published: 25 June 2012
Download PDF [500 KB, uploaded 18 June 2014]
Abstract: Ever since the idea arose that melatonin might promote sleep and resynchronize circadian rhythms, many research groups have centered their efforts on obtaining new melatonin receptor ligands whose pharmacophores include an aliphatic chain of variable length united to an N-alkylamide and a methoxy group (or a bioisostere), linked to a central ring. Substitution of the indole ring found in melatonin with a naphthalene or quinoline ring leads to compounds of similar affinity. The next step in this structural approximation is to introduce a quinoxaline ring (a bioisostere of the quinoline and naphthalene rings) as the central nucleus of future melatoninergic ligands.
Keywords: sleep disorders; melatonin; MT1/MT2 receptors; quinoxalinamide; quinoxalinurea sleep disorders; melatonin; MT1/MT2 receptors; quinoxalinamide; quinoxalinurea
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Ancizu, S.; Castrillo, N.; Pérez-Silanes, S.; Aldana, I.; Monge, A.; Delagrange, P.; Caignard, D.-H.; Galiano, S. New Quinoxaline Derivatives as Potential MT1 and MT2 Receptor Ligands. Molecules 2012, 17, 7737-7757.

AMA Style

Ancizu S, Castrillo N, Pérez-Silanes S, Aldana I, Monge A, Delagrange P, Caignard D-H, Galiano S. New Quinoxaline Derivatives as Potential MT1 and MT2 Receptor Ligands. Molecules. 2012; 17(7):7737-7757.

Chicago/Turabian Style

Ancizu, Saioa; Castrillo, Nerea; Pérez-Silanes, Silvia; Aldana, Ignacio; Monge, Antonio; Delagrange, Philippe; Caignard, Daniel-Henry; Galiano, Silvia. 2012. "New Quinoxaline Derivatives as Potential MT1 and MT2 Receptor Ligands." Molecules 17, no. 7: 7737-7757.


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