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Molecules 2012, 17(7), 7695-7708; doi:10.3390/molecules17077695

Restoration of Electric Footshock-Induced Immunosuppression in Mice by Gynostemma pentaphyllum Components

College of Pharmacy, Chungbuk National University, Cheongju 361-763, Korea
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Received: 17 February 2012 / Revised: 11 June 2012 / Accepted: 20 June 2012 / Published: 25 June 2012
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Abstract

The immunomodulatory effects of the ethanol extract of Gynostemma pentaphyllum (GP-EX) were examined in electric footshock (EFS)-stressed mice. The mice were orally administered various doses of GP-EX for 7 days before exposure to EFS (duration: 3 min, interval: 10 s, intensity: 2 mA) once a day from day 8 for 14 days with continuous daily feeding of GP-EX. Oral administration of GP-EX to mice prevented EFS stress-induced immunosuppression as determined by the lymphoid organ (thymus and spleen) weight and cellularity. In addition, oral administration of GP-EX restored EFS-suppressed functional properties of mature lymphocytes in terms of concanavalin A-induced proliferation of splenocytes and lipopolysaccharide-induced cytokine production (TNF-α, IL-1β). Furthermore, we found that mice that were orally administered with GP-EX generated much more potent ovalbumin-specific cytotoxic T lymphocyte responses upon intravenous ovalbumin injection compared to the untreated controls. These results demonstrate that oral administration of the ethanol extract of Gynostemma pentaphyllum could increase host defense in immunocompromised situations such as stress-induced immunosuppression.
Keywords: Gynostemma pentaphyllum; electric footshock; stress; immunomodulation; cytotoxic T lymphocytes Gynostemma pentaphyllum; electric footshock; stress; immunomodulation; cytotoxic T lymphocytes
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Im, S.-A.; Choi, H.S.; Choi, S.O.; Kim, K.-H.; Lee, S.; Hwang, B.Y.; Lee, M.K.; Lee, C.K. Restoration of Electric Footshock-Induced Immunosuppression in Mice by Gynostemma pentaphyllum Components. Molecules 2012, 17, 7695-7708.

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