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Molecules 2012, 17(6), 7284-7293; doi:10.3390/molecules17067284
Article

Antibacterial, Antifungal and Cytotoxic Activities of Two Flavonoids from Retama raetam Flowers

1
,
2
,
3
,
2
,
1
 and
4,5,*
1 Laboratoire des Maladies Transmissibles et des Substances Biologiquement Actives, Faculté de Pharmacie, Monastir 5000, Tunisia 2 Laboratoire de Microbiologie C H U Fattouma BOURGUIBA, Monastir 5000, Tunisia 3 Laboratoire de Chimie des Substances Naturelles et de Synthèse Organique 99/UR/12-26, Faculté des Sciences de Monastir, Monastir 5000, Tunisia 4 Division of Toxicology, Scientific Institute of Public Health, Brussels B-1050, Belgium 5 Department of Biomedical Sciences, University of Antwerp, Wilrijk 2610, Belgium
* Author to whom correspondence should be addressed.
Received: 16 May 2012 / Revised: 29 May 2012 / Accepted: 6 June 2012 / Published: 13 June 2012
(This article belongs to the Section Natural Products)
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Abstract

We have investigated the antibacterial, antifungal and cytotoxic activities of two flavonoids isolated from Retama raetam flowers using the disc diffusion and micro-dilution broth methods. The cytotoxic activity was tested against Hep-2 cells using the MTT assay. The compounds licoflavone C (1) and derrone (2) were active against Pseudomonas aeruginosa and Escherichia coli (7.81–15.62 µg/mL) and showed important antifungal activity. Strong antifungal activity against Candida species (7.81 µg/mL) was for example found with compound 2. The tested compounds also showed strong cytotoxicity against Hep-2 cells. These two compounds may be interesting antimicrobial agents to be used against infectious diseases caused by many pathogens.
Keywords: Retama raetam flowers; antibacterial activity; antifungal activity; cytotoxic property; flavonoid Retama raetam flowers; antibacterial activity; antifungal activity; cytotoxic property; flavonoid
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Edziri, H.; Mastouri, M.; Mahjoub, M.A.; Mighri, Z.; Mahjoub, A.; Verschaeve, L. Antibacterial, Antifungal and Cytotoxic Activities of Two Flavonoids from Retama raetam Flowers. Molecules 2012, 17, 7284-7293.

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