Next Article in Journal
Antioxidant Activity of Various Parts of Cinnamomum cassia Extracted with Different Extraction Methods
Previous Article in Journal
Hypervalent Nonbonded Interactions of a Divalent Sulfur Atom. Implications in Protein Architecture and the Functions
Molecules 2012, 17(6), 7284-7293; doi:10.3390/molecules17067284
Article

Antibacterial, Antifungal and Cytotoxic Activities of Two Flavonoids from Retama raetam Flowers

1
,
2
,
3
,
2
,
1
 and
4,5,*
Received: 16 May 2012 / Revised: 29 May 2012 / Accepted: 6 June 2012 / Published: 13 June 2012
(This article belongs to the Section Metabolites)
Download PDF [200 KB, uploaded 18 June 2014]

Abstract

We have investigated the antibacterial, antifungal and cytotoxic activities of two flavonoids isolated from Retama raetam flowers using the disc diffusion and micro-dilution broth methods. The cytotoxic activity was tested against Hep-2 cells using the MTT assay. The compounds licoflavone C (1) and derrone (2) were active against Pseudomonas aeruginosa and Escherichia coli (7.81–15.62 µg/mL) and showed important antifungal activity. Strong antifungal activity against Candida species (7.81 µg/mL) was for example found with compound 2. The tested compounds also showed strong cytotoxicity against Hep-2 cells. These two compounds may be interesting antimicrobial agents to be used against infectious diseases caused by many pathogens.
Keywords: Retama raetam flowers; antibacterial activity; antifungal activity; cytotoxic property; flavonoid Retama raetam flowers; antibacterial activity; antifungal activity; cytotoxic property; flavonoid
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
EndNote
MDPI and ACS Style

Edziri, H.; Mastouri, M.; Mahjoub, M.A.; Mighri, Z.; Mahjoub, A.; Verschaeve, L. Antibacterial, Antifungal and Cytotoxic Activities of Two Flavonoids from Retama raetam Flowers. Molecules 2012, 17, 7284-7293.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here

Comments

Cited By

[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert