Molecules 2012, 17(6), 7284-7293; doi:10.3390/molecules17067284
Article

Antibacterial, Antifungal and Cytotoxic Activities of Two Flavonoids from Retama raetam Flowers

1email, 2email, 3email, 2email, 1email and 4,5,* email
Received: 16 May 2012; in revised form: 29 May 2012 / Accepted: 6 June 2012 / Published: 13 June 2012
(This article belongs to the Section Metabolites)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: We have investigated the antibacterial, antifungal and cytotoxic activities of two flavonoids isolated from Retama raetam flowers using the disc diffusion and micro-dilution broth methods. The cytotoxic activity was tested against Hep-2 cells using the MTT assay. The compounds licoflavone C (1) and derrone (2) were active against Pseudomonas aeruginosa and Escherichia coli (7.81–15.62 µg/mL) and showed important antifungal activity. Strong antifungal activity against Candida species (7.81 µg/mL) was for example found with compound 2. The tested compounds also showed strong cytotoxicity against Hep-2 cells. These two compounds may be interesting antimicrobial agents to be used against infectious diseases caused by many pathogens.
Keywords: Retama raetam flowers; antibacterial activity; antifungal activity; cytotoxic property; flavonoid
PDF Full-text Download PDF Full-Text [200 KB, uploaded 18 June 2014 19:49 CEST]

Export to BibTeX |
EndNote


MDPI and ACS Style

Edziri, H.; Mastouri, M.; Mahjoub, M.A.; Mighri, Z.; Mahjoub, A.; Verschaeve, L. Antibacterial, Antifungal and Cytotoxic Activities of Two Flavonoids from Retama raetam Flowers. Molecules 2012, 17, 7284-7293.

AMA Style

Edziri H, Mastouri M, Mahjoub MA, Mighri Z, Mahjoub A, Verschaeve L. Antibacterial, Antifungal and Cytotoxic Activities of Two Flavonoids from Retama raetam Flowers. Molecules. 2012; 17(6):7284-7293.

Chicago/Turabian Style

Edziri, Hayet; Mastouri, Maha; Mahjoub, Mohamed Ali; Mighri, Zine; Mahjoub, Aouni; Verschaeve, Luc. 2012. "Antibacterial, Antifungal and Cytotoxic Activities of Two Flavonoids from Retama raetam Flowers." Molecules 17, no. 6: 7284-7293.

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert