Next Article in Journal
The Potential Biotechnological Applications of the Exopolysaccharide Produced by the Halophilic Bacterium Halomonas almeriensis
Previous Article in Journal
Astragalus Polysaccharide Improves Palmitate-Induced Insulin Resistance by Inhibiting PTP1B and NF-κB in C2C12 Myotubes
Article Menu

Article Versions

Export Article

Open AccessArticle
Molecules 2012, 17(6), 7093-7102; doi:10.3390/molecules17067093

Lycopene Effects on Serum Mineral Elements and Bone Strength in Rats

1
Hands and Feet Microsurgery, Dalian Municipal Central Hospital, Dalian 116033, China
2
School of Medicine, Dalian University, Dalian 116033, China
*
Author to whom correspondence should be addressed.
Received: 5 April 2012 / Revised: 23 May 2012 / Accepted: 4 June 2012 / Published: 11 June 2012
Download PDF [170 KB, uploaded 18 June 2014]

Abstract

This study investigated the beneficial effect of lycopene on bone biomarkers in ovariectomized (OVX) rats. Female Wistar rats were either sham operated or surgically ovariectomized and then fed with lycopene for 8 weeks. Serum Ca, P, alkaline phosphatase (ALP), interleukin 6 (IL-6) and bone gla protein (BGP) concentration was significantly higher in the untreated OVX group compared with that of the sham group, whereas serum estrogen levels were lower. Bone mineral density (BMD), BMD/wt, bone mineral content (BMC), BMC/wt values, maximum load, stiffness, energy and maximum stress were significantly lower in the untreated OVX group compared with that of the sham group. Administration of lycopene (20, 30 and 40 mg/kg b.w.) for 8 weeks significantly decreased serum Ca, P, ALP, and IL-6 concentration, and enhanced serum estrogen level, BMD, BMD/wt, BMC, BMC/wt values, maximum load, stiffness, energy and maximum stress in lycopene-treated OVX groups. In conclusion, the consumption of lycopene may have the most protective effect on bone in OVX rats.
Keywords: lycopene; biomarkers; BGP; maximum load; maximum stress lycopene; biomarkers; BGP; maximum load; maximum stress
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Liang, H.; Yu, F.; Tong, Z.; Zeng, W. Lycopene Effects on Serum Mineral Elements and Bone Strength in Rats. Molecules 2012, 17, 7093-7102.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top