Molecules 2012, 17(6), 7093-7102; doi:10.3390/molecules17067093
Article

Lycopene Effects on Serum Mineral Elements and Bone Strength in Rats

1 Hands and Feet Microsurgery, Dalian Municipal Central Hospital, Dalian 116033, China 2 School of Medicine, Dalian University, Dalian 116033, China
* Author to whom correspondence should be addressed.
Received: 5 April 2012; in revised form: 23 May 2012 / Accepted: 4 June 2012 / Published: 11 June 2012
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Abstract: This study investigated the beneficial effect of lycopene on bone biomarkers in ovariectomized (OVX) rats. Female Wistar rats were either sham operated or surgically ovariectomized and then fed with lycopene for 8 weeks. Serum Ca, P, alkaline phosphatase (ALP), interleukin 6 (IL-6) and bone gla protein (BGP) concentration was significantly higher in the untreated OVX group compared with that of the sham group, whereas serum estrogen levels were lower. Bone mineral density (BMD), BMD/wt, bone mineral content (BMC), BMC/wt values, maximum load, stiffness, energy and maximum stress were significantly lower in the untreated OVX group compared with that of the sham group. Administration of lycopene (20, 30 and 40 mg/kg b.w.) for 8 weeks significantly decreased serum Ca, P, ALP, and IL-6 concentration, and enhanced serum estrogen level, BMD, BMD/wt, BMC, BMC/wt values, maximum load, stiffness, energy and maximum stress in lycopene-treated OVX groups. In conclusion, the consumption of lycopene may have the most protective effect on bone in OVX rats.
Keywords: lycopene; biomarkers; BGP; maximum load; maximum stress

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MDPI and ACS Style

Liang, H.; Yu, F.; Tong, Z.; Zeng, W. Lycopene Effects on Serum Mineral Elements and Bone Strength in Rats. Molecules 2012, 17, 7093-7102.

AMA Style

Liang H, Yu F, Tong Z, Zeng W. Lycopene Effects on Serum Mineral Elements and Bone Strength in Rats. Molecules. 2012; 17(6):7093-7102.

Chicago/Turabian Style

Liang, Haidong; Yu, Fang; Tong, Zhihong; Zeng, Weifeng. 2012. "Lycopene Effects on Serum Mineral Elements and Bone Strength in Rats." Molecules 17, no. 6: 7093-7102.

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