Next Article in Journal
Synthesis of a 2,2'-Bipyridyl Functionalized Oligovinylene-Phenylene Using Heck and Horner-Wadsworth-Emmons Reactions and X-ray Crystal Structure of E-(4-(4-Bromostyryl)phenyl)(methyl)sulfane
Previous Article in Journal
QSAR Modeling on Benzo[c]phenanthridine Analogues as Topoisomerase I Inhibitors and Anti-cancer Agents
Molecules 2012, 17(5), 5713-5723; doi:10.3390/molecules17055713
Article

Antifungal Activities of New Coumarins

1,2,* , 1 and 1
1 Chemical Engineering Faculty, University of Kabengassan Malaysia (UKM), Selangor 43000, Malaysia 2 Applied Chemistry division, Applied Science Department, University of Technology UOT), Baghdad 10066, Iraq
* Author to whom correspondence should be addressed.
Received: 31 March 2012 / Revised: 12 April 2012 / Accepted: 20 April 2012 / Published: 14 May 2012
(This article belongs to the Section Medicinal Chemistry)
Download PDF [1086 KB, uploaded 18 June 2014]

Abstract

Newly synthesized coumarins 4-((5-mercapto-4-phenyl-4H-1,2,4-triazol-3-yl)-methoxy)-2H-chromen-2-one and 4-((5-(phenylamino)-1,3,4-thiadiazol-2-yl)-methoxy)-2H-chromen-2-one were tested against selected types of fungi and showed significant activities. DFT calculations of the synthesized coumarins were performed using molecular structures with optimized geometries. Molecular orbital calculations provide a detailed description of the orbitals, including spatial characteristics, nodal patterns, and the contributions of individual atoms.
Keywords: antifungal; 4-aminoantipyrine; benzyl bromide; coumarins; DFT; ethyl bromoacetate; 4-hydroxycoumarin antifungal; 4-aminoantipyrine; benzyl bromide; coumarins; DFT; ethyl bromoacetate; 4-hydroxycoumarin
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Export to BibTeX |
EndNote


MDPI and ACS Style

Al-Amiery, A.A.; Kadhum, A.A.H.; Mohamad, A.B. Antifungal Activities of New Coumarins. Molecules 2012, 17, 5713-5723.

View more citation formats

Related Articles

Article Metrics

Comments

Citing Articles

[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert