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Molecules 2012, 17(5), 5396-5403; doi:10.3390/molecules17055396

Two New Cyanogenic Glucosides from the Leaves of Hydrangea macrophylla

1 College of Pharmacy, Harbin Medical University, No. 157 Baojian Road, Nangang District, Harbin 150081, China 2 Key Laboratory of Chinese Materia Medica (Ministry of Education), Heilongjiang University of Chinese Medicine, Harbin 150040, China 3 Department of Pharmacy, the Second Affiliated Hospital of Harbin Medical University, Harbin 150086, China
* Author to whom correspondence should be addressed.
Received: 27 March 2012 / Revised: 22 April 2012 / Accepted: 27 April 2012 / Published: 8 May 2012
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Chemical investigation of the ethanol extract of the aerial parts of Hydrangea macrophylla collected in the Sichuan Province of China resulted in the isolation of two new cyanogenic glucosides. Their structures were elucidated as [(2R)-2-(b-D-glucopyranosyloxy)-2-(3,4-dimethoxy-phenyl)] acetonitrile (1) and {(2R)-2-[a-D-glucopyranosyl(1®6)b-D-glucopyranosyloxy]-2-(3-hydroxy-4-methoxy-phenyl)}acetonitrile (2) on the basis of extensive spectroscopic analysis (1D, 2D NMR and HRESIMS) and chemical studies.
Keywords: Hydrangea macrophylla; Saxifragaceae; cyanogenic glucoside Hydrangea macrophylla; Saxifragaceae; cyanogenic glucoside
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Yang, C.-J.; Wang, Z.-B.; Zhu, D.-L.; Yu, Y.; Lei, Y.-T.; Liu, Y. Two New Cyanogenic Glucosides from the Leaves of Hydrangea macrophylla. Molecules 2012, 17, 5396-5403.

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