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Immunostimulatory Effect of Laminarin on RAW 264.7 Mouse Macrophages
AbstractThis study investigated the immunostimulatory effects of laminarin with respect to inflammatory mediators such as hydrogen peroxide, calcium, nitric oxide, various cytokines, transcription factors, and immune response gene in RAW 264.7 mouse macrophages. Laminarin did not reduce the cell proliferation of RAW 264.7 mouse macrophages at concentrations up to 500 µg/mL. Laminarin significantly increased the release of hydrogen peroxide, calcium, nitric oxide, monocyte chemotactic protein-1, vascular endothelial growth factor, leukemia inhibitory factor, and granulocyte-colony stimulating factor with enhancing expression of Signal Transducer and Activator of Transcription 1 (STAT1), STAT3, c-Jun, c-Fos, and cyclooxygenase-2 mRNA in RAW 264.7 cells. The results suggest that laminarin has immunostimulatory properties, strengthening immune reactions via the transcription factor pathway in macrophages.
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Lee, J.Y.; Kim, Y.-J.; Kim, H.J.; Kim, Y.-S.; Park, W. Immunostimulatory Effect of Laminarin on RAW 264.7 Mouse Macrophages. Molecules 2012, 17, 5404-5411.View more citation formats
Lee JY, Kim Y-J, Kim HJ, Kim Y-S, Park W. Immunostimulatory Effect of Laminarin on RAW 264.7 Mouse Macrophages. Molecules. 2012; 17(5):5404-5411.Chicago/Turabian Style
Lee, Ji Young; Kim, Young-Jin; Kim, Hyun Joo; Kim, Yoon-Sang; Park, Wansu. 2012. "Immunostimulatory Effect of Laminarin on RAW 264.7 Mouse Macrophages." Molecules 17, no. 5: 5404-5411.