Molecules 2012, 17(5), 5339-5345; doi:10.3390/molecules17055339
Communication

Synthesis of N-substituted Acridinediones and Polyhydroquinoline Derivatives in Refluxing Water

Received: 13 March 2012; in revised form: 24 April 2012 / Accepted: 28 April 2012 / Published: 7 May 2012
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Acridinediones were synthesized by the one-pot Hantzsch condensation of an aromatic aldehyde, 5,5-dimethyl-1,3-cyclohexanedione, and aniline/4-methylaniline in refluxing water. This method has then been extended to the four-component reaction of an aromatic aldehyde, 5,5-dimethyl-1,3-cyclohexanedione, ethyl acetoacetate and ammonium acetate for the synthesis of polyhydroquinoline derivatives. This is an environmentally friendly and efficient procedure providing good to excellent yields.
Keywords: acridinedione; polyhydroquinoline; one-pot reaction; water
PDF Full-text Download PDF Full-Text [177 KB, uploaded 18 June 2014 19:48 CEST]

Export to BibTeX |
EndNote


MDPI and ACS Style

Xia, J.-J.; Zhang, K.-H. Synthesis of N-substituted Acridinediones and Polyhydroquinoline Derivatives in Refluxing Water. Molecules 2012, 17, 5339-5345.

AMA Style

Xia J-J, Zhang K-H. Synthesis of N-substituted Acridinediones and Polyhydroquinoline Derivatives in Refluxing Water. Molecules. 2012; 17(5):5339-5345.

Chicago/Turabian Style

Xia, Jing-Jing; Zhang, Ke-Hua. 2012. "Synthesis of N-substituted Acridinediones and Polyhydroquinoline Derivatives in Refluxing Water." Molecules 17, no. 5: 5339-5345.

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert