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Molecules 2012, 17(5), 5339-5345; doi:10.3390/molecules17055339
Communication

Synthesis of N-substituted Acridinediones and Polyhydroquinoline Derivatives in Refluxing Water

*  and
Received: 13 March 2012 / Revised: 24 April 2012 / Accepted: 28 April 2012 / Published: 7 May 2012
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Abstract

Acridinediones were synthesized by the one-pot Hantzsch condensation of an aromatic aldehyde, 5,5-dimethyl-1,3-cyclohexanedione, and aniline/4-methylaniline in refluxing water. This method has then been extended to the four-component reaction of an aromatic aldehyde, 5,5-dimethyl-1,3-cyclohexanedione, ethyl acetoacetate and ammonium acetate for the synthesis of polyhydroquinoline derivatives. This is an environmentally friendly and efficient procedure providing good to excellent yields.
Keywords: acridinedione; polyhydroquinoline; one-pot reaction; water acridinedione; polyhydroquinoline; one-pot reaction; water
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Xia, J.-J.; Zhang, K.-H. Synthesis of N-substituted Acridinediones and Polyhydroquinoline Derivatives in Refluxing Water. Molecules 2012, 17, 5339-5345.

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