Diterpenoid Alkaloids from the Chinese Traditional Herbal “Fuzi” and Their Cytotoxic Activity
Abstract
:1. Introduction
2. Results and Discussion
Compds | IC50 (×10−8 M) | Compds | IC50 (×10−8 M) | ||||
---|---|---|---|---|---|---|---|
HCT8 | MCF7 | HePG2 | HCT8 | MCF7 | HePG2 | ||
Taxol | 4.49 ± 0.83 | 0.71 ± 0.25 | 0.12 ± 0.47 | Taxol | 4.49 ± 0.83 | 0.71 ± 0.25 | 0.12 ± 0.47 |
1 | 8.12 ± 0.23 | 2.45 ± 1.02 | 0.85 ± 0.06 | 6 | 12.05 ± 0.76 | 6.46 ± 1.26 | 0.92 ± 0.06 |
2 | >1,000 | >1,000 | >1,000 | 7 | 13.16 ± 1.58 | 4.57 ± 0.29 | 1.45 ± 0.01 |
3 | 16.45 ± 1.55 | 12.86 ± 3.52 | 2.36 ± 0.42 | 8 | >1,000 | >1,000 | >1,000 |
4 | 29.48 ± 3.12 | 3.13 ± 0.14 | 8.61 ± 1.31 | 9 | >1,000 | >1,000 | >1,000 |
5 | 5.14 ± 0.68 | 10.35 ± 1.24 | 9.21 ± 2.33 | 10 | >1,000 | >1,000 | 58.55 ± 9.17 |
3. Experimental
3.1. General
3.2. Plant Material Collection and Identification
3.3. Extraction and Isolation
3.4. NMR Spectroscopic Data
3.5. Determination of Cell Viability by MTT Assay
4. Conclusions
Acknowledgments
- Samples Availability: Samples of the compounds 1–3, 5–7, and 9 are available from the corresponding author.
References and Notes
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Gao, F.; Li, Y.-Y.; Wang, D.; Huang, X.; Liu, Q. Diterpenoid Alkaloids from the Chinese Traditional Herbal “Fuzi” and Their Cytotoxic Activity. Molecules 2012, 17, 5187-5194. https://doi.org/10.3390/molecules17055187
Gao F, Li Y-Y, Wang D, Huang X, Liu Q. Diterpenoid Alkaloids from the Chinese Traditional Herbal “Fuzi” and Their Cytotoxic Activity. Molecules. 2012; 17(5):5187-5194. https://doi.org/10.3390/molecules17055187
Chicago/Turabian StyleGao, Feng, Yuan-Yuan Li, Dan Wang, Xing Huang, and Qian Liu. 2012. "Diterpenoid Alkaloids from the Chinese Traditional Herbal “Fuzi” and Their Cytotoxic Activity" Molecules 17, no. 5: 5187-5194. https://doi.org/10.3390/molecules17055187