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Molecules 2012, 17(3), 3243-3258; doi:10.3390/molecules17033243

Biodegradability and Biocompatibility Study of Poly(Chitosan-g-lactic Acid) Scaffolds

1,2
and
1,2,*
1
Institute of Biochemical and Biotechnological Drugs, School of Pharmacy, Shandong University, Jinan 250012, China
2
National Glycoengineering Research Center, Shandong University, Jinan 250012, China
*
Author to whom correspondence should be addressed.
Received: 6 February 2012 / Revised: 26 February 2012 / Accepted: 12 March 2012 / Published: 14 March 2012
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Abstract

A biodegradable, biocompatible poly(chitosan-g-lactic acid) (PCLA) scaffold was prepared and evaluated in vitro and in vivo. The PCLA scaffold was obtained by grafting lactic acid (LA) onto the amino groups on chitosan (CS) without a catalyst. The PCLA scaffolds were characterized by Fourier Transform infrared spectroscopy (FT-IR) and scanning electron microscopy (SEM). The biodegradabilty was determined by mass loss in vitro, and degradation in vivo as a function of feed ratio of LA/CS. Bone marrow mesenchymal stem cell (BMSC) culture experiments and histological examination were performed to evaluate the PCLA scaffolds’ biocompatibility. The results indicated that PCLA was promising for tissue engineering application.
Keywords: chitosan; lactic acid; scaffold; biodegradable; biocompatible chitosan; lactic acid; scaffold; biodegradable; biocompatible
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Zhang, Z.; Cui, H. Biodegradability and Biocompatibility Study of Poly(Chitosan-g-lactic Acid) Scaffolds. Molecules 2012, 17, 3243-3258.

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