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Molecules 2012, 17(2), 1860-1869; doi:10.3390/molecules17021860
Article

An Efficient Three Component One-Pot Synthesis of 5-Amino-7-aryl-7,8-dihydro-[1,2,4] triazolo[4,3-a]-pyrimidine-6-carbonitriles

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Received: 11 January 2012; in revised form: 30 January 2012 / Accepted: 30 January 2012 / Published: 14 February 2012
(This article belongs to the Section Organic Synthesis)
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Abstract: A series of novel 5-amino-7-aryl-7,8-dihydro-[1,2,4] triazolo[4,3-a]-pyrimidine-6-carbonitriles were synthesized by a one-pot reaction of 3-amino-1,2,4-triazole, malononitrile and aryl aldehydes in the presence of 20 mol% NaOH in ethanol under heating or ultrasonic irradiation. The structures of the target compounds were confirmed by inspection of their 1H- NMR, 13C-NMR, IR and MS spectra. The advantages of this method are short reaction times, good yields, high selectivity and operational simplicity.
Keywords: 1,2,4-triazolo[4,3-a]pyrimidine; three component reactions; one-pot synthesis; ultrasound irradiation 1,2,4-triazolo[4,3-a]pyrimidine; three component reactions; one-pot synthesis; ultrasound irradiation
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Ablajan, K.; Kamil, W.; Tuoheti, A.; Wan-Fu, S. An Efficient Three Component One-Pot Synthesis of 5-Amino-7-aryl-7,8-dihydro-[1,2,4] triazolo[4,3-a]-pyrimidine-6-carbonitriles. Molecules 2012, 17, 1860-1869.

AMA Style

Ablajan K, Kamil W, Tuoheti A, Wan-Fu S. An Efficient Three Component One-Pot Synthesis of 5-Amino-7-aryl-7,8-dihydro-[1,2,4] triazolo[4,3-a]-pyrimidine-6-carbonitriles. Molecules. 2012; 17(2):1860-1869.

Chicago/Turabian Style

Ablajan, Keyume; Kamil, Wetengul; Tuoheti, Anagu; Wan-Fu, Sun. 2012. "An Efficient Three Component One-Pot Synthesis of 5-Amino-7-aryl-7,8-dihydro-[1,2,4] triazolo[4,3-a]-pyrimidine-6-carbonitriles." Molecules 17, no. 2: 1860-1869.


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