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Molecules 2012, 17(2), 1448-1467; doi:10.3390/molecules17021448
Review

Communic Acids: Occurrence, Properties and Use as Chirons for the Synthesis of Bioactive Compounds

1,* , 1,* , 1
,
2
 and
3
Received: 25 November 2011 / Revised: 31 January 2012 / Accepted: 31 January 2012 / Published: 6 February 2012
(This article belongs to the Special Issue Terpenoids)
Download PDF [569 KB, 18 June 2014; original version 18 June 2014]

Abstract

Communic acids are diterpenes with labdane skeletons found in many plant species, mainly conifers, predominating in the genus Juniperus (fam. Cupresaceae). In this review we briefly describe their distribution and different biological activities (anti- bacterial, antitumoral, hypolipidemic, relaxing smooth muscle, etc.). This paper also includes a detailed explanation of their use as chiral building blocks for the synthesis of bioactive natural products. Among other uses, communic acids have proven useful as chirons for the synthesis of quassinoids (formal), abietane antioxidants, ambrox and other perfume fixatives, podolactone herbicides, etc., featuring shorter and more efficient processes.
Keywords: communic acids; labdanes; bioactivity; synthesis; chirons communic acids; labdanes; bioactivity; synthesis; chirons
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Barrero, A.F.; Herrador, M.M.; Arteaga, P.; Arteaga, J.F.; Arteaga, A.F. Communic Acids: Occurrence, Properties and Use as Chirons for the Synthesis of Bioactive Compounds. Molecules 2012, 17, 1448-1467.

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