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Molecules 2012, 17(2), 1448-1467; doi:10.3390/molecules17021448

Communic Acids: Occurrence, Properties and Use as Chirons for the Synthesis of Bioactive Compounds

1
Departamento de Química Orgánica, Facultad de Ciencias, Instituto de Biotecnología, Universidad de Granada, Campus de Fuente Nueva, s/n. 18071 Granada, Spain
2
Departamento de Ingeniería Química, Química Fisíca y Químíca Orgánica, Facultad de Ciencias Experimentales, Universidad de Huelva, Campus el Carmen, s/n, 21071, Huelva, Spain
3
Departamento de Ingeniería Química, Facultad de Ciencias, Universidad de Granada, Campus de Fuente Nueva, s/n. 18071 Granada, Spain
*
Authors to whom correspondence should be addressed.
Received: 25 November 2011 / Revised: 31 January 2012 / Accepted: 31 January 2012 / Published: 6 February 2012
(This article belongs to the Special Issue Terpenoids)
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Abstract

Communic acids are diterpenes with labdane skeletons found in many plant species, mainly conifers, predominating in the genus Juniperus (fam. Cupresaceae). In this review we briefly describe their distribution and different biological activities (anti- bacterial, antitumoral, hypolipidemic, relaxing smooth muscle, etc.). This paper also includes a detailed explanation of their use as chiral building blocks for the synthesis of bioactive natural products. Among other uses, communic acids have proven useful as chirons for the synthesis of quassinoids (formal), abietane antioxidants, ambrox and other perfume fixatives, podolactone herbicides, etc., featuring shorter and more efficient processes.
Keywords: communic acids; labdanes; bioactivity; synthesis; chirons communic acids; labdanes; bioactivity; synthesis; chirons
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This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Barrero, A.F.; Herrador, M.M.; Arteaga, P.; Arteaga, J.F.; Arteaga, A.F. Communic Acids: Occurrence, Properties and Use as Chirons for the Synthesis of Bioactive Compounds. Molecules 2012, 17, 1448-1467.

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