Molecules 2012, 17(2), 1448-1467; doi:10.3390/molecules17021448
Review

Communic Acids: Occurrence, Properties and Use as Chirons for the Synthesis of Bioactive Compounds

1,* email, 1,* email, 1email, 2email and 3email
Received: 25 November 2011; in revised form: 31 January 2012 / Accepted: 31 January 2012 / Published: 6 February 2012
(This article belongs to the Special Issue Terpenoids)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Communic acids are diterpenes with labdane skeletons found in many plant species, mainly conifers, predominating in the genus Juniperus (fam. Cupresaceae). In this review we briefly describe their distribution and different biological activities (anti- bacterial, antitumoral, hypolipidemic, relaxing smooth muscle, etc.). This paper also includes a detailed explanation of their use as chiral building blocks for the synthesis of bioactive natural products. Among other uses, communic acids have proven useful as chirons for the synthesis of quassinoids (formal), abietane antioxidants, ambrox and other perfume fixatives, podolactone herbicides, etc., featuring shorter and more efficient processes.
Keywords: communic acids; labdanes; bioactivity; synthesis; chirons
PDF Full-text Download PDF Full-Text [569 KB, Updated Version, uploaded 18 June 2014 19:44 CEST]
The original version is still available [562 KB, uploaded 18 June 2014 19:44 CEST]

Export to BibTeX |
EndNote


MDPI and ACS Style

Barrero, A.F.; Herrador, M.M.; Arteaga, P.; Arteaga, J.F.; Arteaga, A.F. Communic Acids: Occurrence, Properties and Use as Chirons for the Synthesis of Bioactive Compounds. Molecules 2012, 17, 1448-1467.

AMA Style

Barrero AF, Herrador MM, Arteaga P, Arteaga JF, Arteaga AF. Communic Acids: Occurrence, Properties and Use as Chirons for the Synthesis of Bioactive Compounds. Molecules. 2012; 17(2):1448-1467.

Chicago/Turabian Style

Barrero, Alejandro F.; Herrador, M. Mar; Arteaga, Pilar; Arteaga, Jesús F.; Arteaga, Alejandro F. 2012. "Communic Acids: Occurrence, Properties and Use as Chirons for the Synthesis of Bioactive Compounds." Molecules 17, no. 2: 1448-1467.

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert