Total Synthesis and Antidepressant Activities of Laetispicine and Its Derivatives

doi:10.3390/molecules17021425

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Molecules 2012, 17(2), 1425-1436; doi:10.3390/molecules17021425

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Total Synthesis and Antidepressant Activities of Laetispicine and Its Derivatives

Shuyi Yao¹, Hui Xie², Li Zhang¹, Tao Meng¹, Yongliang Zhang¹, Xin Wang¹, Lin Chen¹, Shengli Pan² and Jingkang Shen^1,*

¹ State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China ² School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai 201203, China

* Author to whom correspondence should be addressed.

Received: 4 January 2012; in revised form: 16 January 2012 / Accepted: 30 January 2012 / Published: 3 February 2012

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Abstract: The first total synthesis of laetispicine (1a), an amide alkaloid isolated from the stems of Piper laetispicum C.DC (Piperaceae), and the synthesis of some of its derivatives were described. Based on the evaluation of antidepressant activities in the forced swimming test, compounds 1h and 1i were identified as potent and safe antidepressant lead compounds.

Keywords: laetispicine derivatives; antidepressant; total synthesis; forced swimming test

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Cite This Article

MDPI and ACS Style

Yao, S.; Xie, H.; Zhang, L.; Meng, T.; Zhang, Y.; Wang, X.; Chen, L.; Pan, S.; Shen, J. Total Synthesis and Antidepressant Activities of Laetispicine and Its Derivatives. Molecules 2012, 17, 1425-1436.

AMA Style

Yao S, Xie H, Zhang L, Meng T, Zhang Y, Wang X, Chen L, Pan S, Shen J. Total Synthesis and Antidepressant Activities of Laetispicine and Its Derivatives. Molecules. 2012; 17(2):1425-1436.

Chicago/Turabian Style

Yao, Shuyi; Xie, Hui; Zhang, Li; Meng, Tao; Zhang, Yongliang; Wang, Xin; Chen, Lin; Pan, Shengli; Shen, Jingkang. 2012. "Total Synthesis and Antidepressant Activities of Laetispicine and Its Derivatives." Molecules 17, no. 2: 1425-1436.

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