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Molecules 2012, 17(2), 1425-1436; doi:10.3390/molecules17021425
Article

Total Synthesis and Antidepressant Activities of Laetispicine and Its Derivatives

1, 2, 1, 1, 1, 1, 1, 2 and 1,*
1 State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China 2 School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai 201203, China
* Author to whom correspondence should be addressed.
Received: 4 January 2012 / Revised: 16 January 2012 / Accepted: 30 January 2012 / Published: 3 February 2012
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Abstract

The first total synthesis of laetispicine (1a), an amide alkaloid isolated from the stems of Piper laetispicum C.DC (Piperaceae), and the synthesis of some of its derivatives were described. Based on the evaluation of antidepressant activities in the forced swimming test, compounds 1h and 1i were identified as potent and safe antidepressant lead compounds.
Keywords: laetispicine derivatives; antidepressant; total synthesis; forced swimming test laetispicine derivatives; antidepressant; total synthesis; forced swimming test
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Yao, S.; Xie, H.; Zhang, L.; Meng, T.; Zhang, Y.; Wang, X.; Chen, L.; Pan, S.; Shen, J. Total Synthesis and Antidepressant Activities of Laetispicine and Its Derivatives. Molecules 2012, 17, 1425-1436.

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