Molecules 2012, 17(2), 1425-1436; doi:10.3390/molecules17021425
Article

Total Synthesis and Antidepressant Activities of Laetispicine and Its Derivatives

1, 2, 1, 1, 1, 1, 1, 2 and 1,* email
Received: 4 January 2012; in revised form: 16 January 2012 / Accepted: 30 January 2012 / Published: 3 February 2012
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: The first total synthesis of laetispicine (1a), an amide alkaloid isolated from the stems of Piper laetispicum C.DC (Piperaceae), and the synthesis of some of its derivatives were described. Based on the evaluation of antidepressant activities in the forced swimming test, compounds 1h and 1i were identified as potent and safe antidepressant lead compounds.
Keywords: laetispicine derivatives; antidepressant; total synthesis; forced swimming test
PDF Full-text Download PDF Full-Text [293 KB, uploaded 18 June 2014 19:44 CEST]

Export to BibTeX |
EndNote


MDPI and ACS Style

Yao, S.; Xie, H.; Zhang, L.; Meng, T.; Zhang, Y.; Wang, X.; Chen, L.; Pan, S.; Shen, J. Total Synthesis and Antidepressant Activities of Laetispicine and Its Derivatives. Molecules 2012, 17, 1425-1436.

AMA Style

Yao S, Xie H, Zhang L, Meng T, Zhang Y, Wang X, Chen L, Pan S, Shen J. Total Synthesis and Antidepressant Activities of Laetispicine and Its Derivatives. Molecules. 2012; 17(2):1425-1436.

Chicago/Turabian Style

Yao, Shuyi; Xie, Hui; Zhang, Li; Meng, Tao; Zhang, Yongliang; Wang, Xin; Chen, Lin; Pan, Shengli; Shen, Jingkang. 2012. "Total Synthesis and Antidepressant Activities of Laetispicine and Its Derivatives." Molecules 17, no. 2: 1425-1436.

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert