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Molecules 2012, 17(2), 1419-1424; doi:10.3390/molecules17021419
Article

A New Iridoid Glycoside from the Roots of Dipsacus asper

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,
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 and *
State Key Laboratory of Natural Products and Functions, China Pharmaceutical University, Ministry of Education, 24 Tong Jia Xiang, Nanjing 210009, China
* Author to whom correspondence should be addressed.
Received: 13 January 2012 / Revised: 21 January 2012 / Accepted: 30 January 2012 / Published: 3 February 2012
(This article belongs to the Section Metabolites)
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Abstract

A new iridoid glycoside, named loganic acid ethyl ester (1), together with five known compounds: chlorogenic acid (2), caffeic acid (3), loganin (4), cantleyoside (5) and syringaresinol-4′,4′′-O-bis-β-D-glucoside (6) were isolated from the roots of Dipsacus asper. The structure of compound 1 was elucidated on the basis of detailed spectroscopic analyses. Lignan is isolated from Dipsacaceae species for the first time. Compounds 1, 4 and 5 had moderate neuroprotective effects against the Aβ25–35 induced cell death in PC12 cells.
Keywords: Dipsacus asper; iridoid glycoside; loganic acid ethyl ester; neuroprotective effect; Dipsaceae Dipsacus asper; iridoid glycoside; loganic acid ethyl ester; neuroprotective effect; Dipsaceae
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Ji, D.; Zhang, C.; Li, J.; Yang, H.; Shen, J.; Yang, Z. A New Iridoid Glycoside from the Roots of Dipsacus asper. Molecules 2012, 17, 1419-1424.

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