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A New Iridoid Glycoside from the Roots of Dipsacus asper
State Key Laboratory of Natural Products and Functions, China Pharmaceutical University, Ministry of Education, 24 Tong Jia Xiang, Nanjing 210009, China
* Author to whom correspondence should be addressed.
Received: 13 January 2012; in revised form: 21 January 2012 / Accepted: 30 January 2012 / Published: 3 February 2012
Abstract: A new iridoid glycoside, named loganic acid ethyl ester (1), together with five known compounds: chlorogenic acid (2), caffeic acid (3), loganin (4), cantleyoside (5) and syringaresinol-4′,4′′-O-bis-β-D-glucoside (6) were isolated from the roots of Dipsacus asper. The structure of compound 1 was elucidated on the basis of detailed spectroscopic analyses. Lignan is isolated from Dipsacaceae species for the first time. Compounds 1, 4 and 5 had moderate neuroprotective effects against the Aβ25–35 induced cell death in PC12 cells.
Keywords: Dipsacus asper; iridoid glycoside; loganic acid ethyl ester; neuroprotective effect; Dipsaceae
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Ji, D.; Zhang, C.; Li, J.; Yang, H.; Shen, J.; Yang, Z. A New Iridoid Glycoside from the Roots of Dipsacus asper. Molecules 2012, 17, 1419-1424.
Ji D, Zhang C, Li J, Yang H, Shen J, Yang Z. A New Iridoid Glycoside from the Roots of Dipsacus asper. Molecules. 2012; 17(2):1419-1424.
Ji, De; Zhang, Chunfeng; Li, Jingzhi; Yang, Haowei; Shen, Jingyang; Yang, Zhonglin. 2012. "A New Iridoid Glycoside from the Roots of Dipsacus asper." Molecules 17, no. 2: 1419-1424.