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Compounds from the Roots and Rhizomes of Valeriana amurensis Protect against Neurotoxicity in PC12 Cells
Key Laboratory of Chinese Materia Medica (Ministry of Education), Heilongjiang University of Chinese Medicine, No. 24 HePing Road, XiangFang District, Harbin 150040, China
Jiangxi University of Traditional Chinese Medicine, Nanchang 330006, China
These authors contributed equally to this work.
* Author to whom correspondence should be addressed.
Received: 12 November 2012; in revised form: 6 December 2012 / Accepted: 11 December 2012 / Published: 18 December 2012
Abstract: Three new germacrane-type sesquiterpenoids, heishuixiecaoline A–C (compounds 1–3), were isolated along with ten known compounds 4–13 from fraction of Valeriana amurensis roots and rhizomes effective against Alzheimer’s disease (AD). The structures of 1–3 were elucidated on the basis of their spectroscopic data. We also investigated the protective effect of compounds 1–13 on the neurotoxicity of PC12 cells induced by amyloid-beta (Aβ25–25), respectively. As a result, germacrane-type sesquiterpenoids 1–4 and lignans 5–7 were seen to afford protection against Aβ-induced toxicity in PC 12 cells. This study will contribute to revealing the chemical basis for the therapeutic effect of V. amurensis against AD.
Keywords: Valeriana amurensis; germacrane-type sesquiterpenoids; heishuixiecaoline; lignans; PC 12 cell
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MDPI and ACS Style
Wang, Q.; Wang, C.; Zuo, Y.; Wang, Z.; Yang, B.; Kuang, H. Compounds from the Roots and Rhizomes of Valeriana amurensis Protect against Neurotoxicity in PC12 Cells. Molecules 2012, 17, 15013-15021.
Wang Q, Wang C, Zuo Y, Wang Z, Yang B, Kuang H. Compounds from the Roots and Rhizomes of Valeriana amurensis Protect against Neurotoxicity in PC12 Cells. Molecules. 2012; 17(12):15013-15021.
Wang, Qiuhong; Wang, Changfu; Zuo, Yueming; Wang, Zhibin; Yang, Bingyou; Kuang, Haixue. 2012. "Compounds from the Roots and Rhizomes of Valeriana amurensis Protect against Neurotoxicity in PC12 Cells." Molecules 17, no. 12: 15013-15021.