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Molecules 2012, 17(12), 15013-15021; doi:10.3390/molecules171215013
Article

Compounds from the Roots and Rhizomes of Valeriana amurensis Protect against Neurotoxicity in PC12 Cells

1,†
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Received: 12 November 2012 / Revised: 6 December 2012 / Accepted: 11 December 2012 / Published: 18 December 2012
Download PDF [287 KB, 18 June 2014; original version 18 June 2014]

Abstract

Three new germacrane-type sesquiterpenoids, heishuixiecaoline A–C (compounds 13), were isolated along with ten known compounds 413 from fraction of Valeriana amurensis roots and rhizomes effective against Alzheimer’s disease (AD). The structures of 13 were elucidated on the basis of their spectroscopic data. We also investigated the protective effect of compounds 113 on the neurotoxicity of PC12 cells induced by amyloid-beta (Aβ25–25), respectively. As a result, germacrane-type sesquiterpenoids 14 and lignans 57 were seen to afford protection against Aβ-induced toxicity in PC 12 cells. This study will contribute to revealing the chemical basis for the therapeutic effect of V. amurensis against AD.
Keywords: Valeriana amurensis; germacrane-type sesquiterpenoids; heishuixiecaoline; lignans; PC 12 cell Valeriana amurensis; germacrane-type sesquiterpenoids; heishuixiecaoline; lignans; PC 12 cell
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Wang, Q.; Wang, C.; Zuo, Y.; Wang, Z.; Yang, B.; Kuang, H. Compounds from the Roots and Rhizomes of Valeriana amurensis Protect against Neurotoxicity in PC12 Cells. Molecules 2012, 17, 15013-15021.

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