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Molecules 2012, 17(12), 14899-14907; doi:10.3390/molecules171214899
Article

Two New Oleanane-Type Triterpenoids from Platycodi Radix and Anti-proliferative Activity in HSC-T6 Cells

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Received: 9 November 2012 / Revised: 29 November 2012 / Accepted: 30 November 2012 / Published: 13 December 2012
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Abstract

Two new oleanane-type triterpenoids, named platycodonoids A and B (1, 2), together with five known saponins, including platycodin D (3), deapioplatycodin D (4), 3-O-β-D-glucopyranosyl polygalacic acid (5), 3-O-β-D-glucopyranosyl platycodigenin (6) and polygalacin D (7), were isolated from the roots of Platycodon grandiflorum. On the basis of spectral data and chemical evidence, the structures of the new compounds were elucidated as 2β,3β,23,24-tetrahydroxy-28-nor-olean-12-en-16-one (1) and 2β,3β,23,24- tetrahydroxy-28-nor-olean-12-en-16-one-3-O-β-D-glucopyranoside (2). Compounds 17 were evaluated for their in vitro anti-proliferative activity against the HSC-T6 cell line.
Keywords: Platycodon grandiflorum; oleanane-type triterpenoid; triterpenoid saponin Platycodon grandiflorum; oleanane-type triterpenoid; triterpenoid saponin
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Zhan, Q.; Zhang, F.; Sun, L.; Wu, Z.; Chen, W. Two New Oleanane-Type Triterpenoids from Platycodi Radix and Anti-proliferative Activity in HSC-T6 Cells. Molecules 2012, 17, 14899-14907.

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