Molecules 2012, 17(12), 14882-14898; doi:10.3390/molecules171214882
Article

Synthesis and in Vitro Antioxidant Activity Evaluation of 3-Carboxycoumarin Derivatives and QSAR Study of Their DPPH• Radical Scavenging Activity

Francisco J. Martínez-Martínez 1,* email, Rodrigo Said Razo-Hernández 1 , Ana Lilia Peraza-Campos 1 , Manuel Villanueva-García 2 email, Maria Teresa Sumaya-Martínez 3 email, Daniel Jaramillo Cano 1 email and Zeferino Gómez-Sandoval 1,* email
1 Facultad de Ciencias Químicas, Universidad de Colima, kilómetro 9 carretera Colima-Coquimatlán, Col., México, C.P. 28400, Mexico 2 Asociación de Jubilados de la Universidad de Guanajuato, Paseo de la Presa No 77, Guanajuato, Gto., México, C.P. 36000, Mexico 3 Secretaria de Investigación y Posgrado, Universidad Autónoma de Nayarit, Ciudad de la Cultura "Amado Nervo", Boulevard Tepic-Xalisco S/N, Tepic, Nayarit CP 63190, Mexico
* Authors to whom correspondence should be addressed.
Received: 21 September 2012; in revised form: 3 December 2012 / Accepted: 5 December 2012 / Published: 13 December 2012
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Abstract: The in vitro antioxidant activities of eight 3-carboxycoumarin derivatives were assayed by the quantitative 1,1-diphenyl-2-picrylhydrazil (DPPH•) radical scavenging activity method. 3-Acetyl-6-hydroxy-2H-1-benzopyran-2-one (C1) and ethyl 6-hydroxy-2-oxo-2H-1-benzopyran-3-carboxylate (C2) presented the best radical-scavenging activity. A quantitative structure-activity relationship (QSAR) study was performed and correlated with the experimental DPPH• scavenging data. We used structural, geometrical, topological and quantum-chemical descriptors selected with Genetic Algorithms in order to determine which of these parameters are responsible of the observed DPPH• radical scavenging activity. We constructed a back propagation neural network with the hydrophilic factor (Hy) descriptor to generate an adequate architecture of neurons for the system description. The mathematical model showed a multiple determination coefficient of 0.9196 and a root mean squared error of 0.0851. Our results shows that the presence of hydroxyl groups on the ring structure of 3-carboxy-coumarins are correlated with the observed DPPH• radical scavenging activity effects.
Keywords: coumarins; QSAR; DPPH•; artificial neural networks

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Cite This Article

MDPI and ACS Style

Martínez-Martínez, F.J.; Razo-Hernández, R.S.; Peraza-Campos, A.L.; Villanueva-García, M.; Sumaya-Martínez, M.T.; Cano, D.J.; Gómez-Sandoval, Z. Synthesis and in Vitro Antioxidant Activity Evaluation of 3-Carboxycoumarin Derivatives and QSAR Study of Their DPPH• Radical Scavenging Activity. Molecules 2012, 17, 14882-14898.

AMA Style

Martínez-Martínez FJ, Razo-Hernández RS, Peraza-Campos AL, Villanueva-García M, Sumaya-Martínez MT, Cano DJ, Gómez-Sandoval Z. Synthesis and in Vitro Antioxidant Activity Evaluation of 3-Carboxycoumarin Derivatives and QSAR Study of Their DPPH• Radical Scavenging Activity. Molecules. 2012; 17(12):14882-14898.

Chicago/Turabian Style

Martínez-Martínez, Francisco J.; Razo-Hernández, Rodrigo S.; Peraza-Campos, Ana L.; Villanueva-García, Manuel; Sumaya-Martínez, Maria T.; Cano, Daniel J.; Gómez-Sandoval, Zeferino. 2012. "Synthesis and in Vitro Antioxidant Activity Evaluation of 3-Carboxycoumarin Derivatives and QSAR Study of Their DPPH• Radical Scavenging Activity." Molecules 17, no. 12: 14882-14898.

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