Molecules 2012, 17(12), 14205-14218; doi:10.3390/molecules171214205
Article

Synthesis and Antifungal Activity of N-(Substituted pyridinyl)-1-methyl(phenyl)-3-(trifluoromethyl)-1H-pyrazole-4-carboxamide Derivatives

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Received: 18 October 2012; in revised form: 26 November 2012 / Accepted: 27 November 2012 / Published: 30 November 2012
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: A series of N-(substituted pyridinyl)-1-methyl(phenyl)-3-trifluoromethyl-1H-pyrazole-4-carboxamide derivatives were synthesized. All target compounds were characterized by spectral data (1H-NMR, 13C-NMR, IR, MS) and elemental analysis and were bioassayed in vitro against three kinds of phytopathogenic fungi (Gibberella zeae, Fusarium oxysporum, Cytospora mandshurica). The results showed that some of the synthesized N-(substituted pyridinyl)-1-methyl-3-trifluoromethyl-1H-pyrazole-4-carboxamides exhibited moderate antifungal activities, among which compounds 6a, 6b and 6c displayed more than 50% inhibition activities against G. zeae at 100 µg/mL, which was better than that of the commercial fungicides carboxin and boscalid.
Keywords: pyrazolecarboxamide derivatives; synthesis; antifungal activity; fungi
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MDPI and ACS Style

Wu, Z.; Hu, D.; Kuang, J.; Cai, H.; Wu, S.; Xue, W. Synthesis and Antifungal Activity of N-(Substituted pyridinyl)-1-methyl(phenyl)-3-(trifluoromethyl)-1H-pyrazole-4-carboxamide Derivatives. Molecules 2012, 17, 14205-14218.

AMA Style

Wu Z, Hu D, Kuang J, Cai H, Wu S, Xue W. Synthesis and Antifungal Activity of N-(Substituted pyridinyl)-1-methyl(phenyl)-3-(trifluoromethyl)-1H-pyrazole-4-carboxamide Derivatives. Molecules. 2012; 17(12):14205-14218.

Chicago/Turabian Style

Wu, Zhibing; Hu, Deyu; Kuang, Jiqing; Cai, Hua; Wu, Shixi; Xue, Wei. 2012. "Synthesis and Antifungal Activity of N-(Substituted pyridinyl)-1-methyl(phenyl)-3-(trifluoromethyl)-1H-pyrazole-4-carboxamide Derivatives." Molecules 17, no. 12: 14205-14218.

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