Next Article in Journal
By Improving Regional Cortical Blood Flow, Attenuating Mitochondrial Dysfunction and Sequential Apoptosis Galangin Acts as a Potential Neuroprotective Agent after Acute Ischemic Stroke
Next Article in Special Issue
Nucleoside Triphosphates — Building Blocks for the Modification of Nucleic Acids
Previous Article in Journal
Endo-S-c-di-GMP Analogues-Polymorphism and Binding Studies with Class I Riboswitch
Previous Article in Special Issue
DNA as a Chiral Scaffold for Asymmetric Synthesis
Article Menu

Article Versions

Export Article

Open AccessArticle
Molecules 2012, 17(11), 13390-13402; doi:10.3390/molecules171113390

Spatial Control of DNA Reaction Networks by DNA Sequence

Institute of Cell and Molecular Biology, University of Texas at Austin, 1 University Station A4800, Austin, TX 78712-0159, USA
Author to whom correspondence should be addressed.
Received: 25 September 2012 / Revised: 5 November 2012 / Accepted: 5 November 2012 / Published: 9 November 2012
(This article belongs to the Special Issue DNA-Directed Chemistry)
Download PDF [578 KB, uploaded 18 June 2014]


We have developed a set of DNA circuits that execute during gel electrophoresis to yield immobile, fluorescent features in the gel. The parallel execution of orthogonal circuits led to the simultaneous production of different fluorescent lines at different positions in the gel. The positions of the lines could be rationally manipulated by changing the mobilities of the reactants. The ability to program at the nanoscale so as to produce patterns at the macroscale is a step towards programmable, synthetic chemical systems for generating defined spatiotemporal patterns.
Keywords: reaction-diffusion; electrophoresis; chemical reaction networks; DNA circuits; strand displacement reactions reaction-diffusion; electrophoresis; chemical reaction networks; DNA circuits; strand displacement reactions
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Allen, P.B.; Chen, X.; Ellington, A.D. Spatial Control of DNA Reaction Networks by DNA Sequence. Molecules 2012, 17, 13390-13402.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top