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Spatial Control of DNA Reaction Networks by DNA Sequence
Institute of Cell and Molecular Biology, University of Texas at Austin, 1 University Station A4800, Austin, TX 78712-0159, USA
* Author to whom correspondence should be addressed.
Received: 25 September 2012; in revised form: 5 November 2012 / Accepted: 5 November 2012 / Published: 9 November 2012
Abstract: We have developed a set of DNA circuits that execute during gel electrophoresis to yield immobile, fluorescent features in the gel. The parallel execution of orthogonal circuits led to the simultaneous production of different fluorescent lines at different positions in the gel. The positions of the lines could be rationally manipulated by changing the mobilities of the reactants. The ability to program at the nanoscale so as to produce patterns at the macroscale is a step towards programmable, synthetic chemical systems for generating defined spatiotemporal patterns.
Keywords: reaction-diffusion; electrophoresis; chemical reaction networks; DNA circuits; strand displacement reactions
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Cite This Article
MDPI and ACS Style
Allen, P.B.; Chen, X.; Ellington, A.D. Spatial Control of DNA Reaction Networks by DNA Sequence. Molecules 2012, 17, 13390-13402.
Allen PB, Chen X, Ellington AD. Spatial Control of DNA Reaction Networks by DNA Sequence. Molecules. 2012; 17(11):13390-13402.
Allen, Peter B.; Chen, Xi; Ellington, Andrew D. 2012. "Spatial Control of DNA Reaction Networks by DNA Sequence." Molecules 17, no. 11: 13390-13402.