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Molecules 2012, 17(11), 13390-13402; doi:10.3390/molecules171113390

Spatial Control of DNA Reaction Networks by DNA Sequence

Institute of Cell and Molecular Biology, University of Texas at Austin, 1 University Station A4800, Austin, TX 78712-0159, USA
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Received: 25 September 2012 / Revised: 5 November 2012 / Accepted: 5 November 2012 / Published: 9 November 2012
(This article belongs to the Special Issue DNA-Directed Chemistry)
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Abstract

We have developed a set of DNA circuits that execute during gel electrophoresis to yield immobile, fluorescent features in the gel. The parallel execution of orthogonal circuits led to the simultaneous production of different fluorescent lines at different positions in the gel. The positions of the lines could be rationally manipulated by changing the mobilities of the reactants. The ability to program at the nanoscale so as to produce patterns at the macroscale is a step towards programmable, synthetic chemical systems for generating defined spatiotemporal patterns.
Keywords: reaction-diffusion; electrophoresis; chemical reaction networks; DNA circuits; strand displacement reactions reaction-diffusion; electrophoresis; chemical reaction networks; DNA circuits; strand displacement reactions
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Allen, P.B.; Chen, X.; Ellington, A.D. Spatial Control of DNA Reaction Networks by DNA Sequence. Molecules 2012, 17, 13390-13402.

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