Next Article in Journal
Two New Glycosides from the Fruits of Morinda citrifolia L.
Previous Article in Journal
Two Novel Phenolic Compounds from the Rhizomes of Cyperus rotundus L.
Article Menu

Export Article

Open AccessArticle
Molecules 2012, 17(11), 12642-12650; doi:10.3390/molecules171112642

New Bioactive Alkyl Sulfates from Mediterranean Tunicates

1
The NeaNat Group, Dipartimento di Chimica delle Sostanze Naturali, Università degli Studi di Napoli “Federico II”, Via D. Montesano 49, 80131, Napoli, Italy
2
C.S.I.A.S. (Centro Servizi Interdipartimentale di Analisi Strumentale), Università degli Studi di Napoli “Federico II”, Via D. Montesano 49, 80131, Napoli, Italy
3
Dipartimento di Farmacologia Sperimentale, Università degli Studi di Napoli “Federico II”, Via D. Montesano 49, 80131, Napoli, Italy
*
Author to whom correspondence should be addressed.
Received: 29 September 2012 / Revised: 22 October 2012 / Accepted: 23 October 2012 / Published: 26 October 2012
(This article belongs to the Section Natural Products)
View Full-Text   |   Download PDF [184 KB, uploaded 18 June 2014]   |  

Abstract

Chemical investigation of two species of marine ascidians, Aplidium elegans and Ciona edwardsii, collected in Mediterranean area, led to isolation of a series of alkyl sulfates (compounds 15) including three new molecules 13. Structures of the new metabolites have been elucidated by spectroscopic analysis. Based on previously reported cytotoxic activity of these type of molecules, compounds 13 have been tested for their effects on the growth of two cell lines, J774A.1 (BALB/c murine macrophages) and C6 (rat glioma) in vitro. Compounds 1 and 2 induced selective concentration-dependent mortality on J774A.1 cells. View Full-Text
Keywords: natural products; alkyl sulfate; cytotoxic activity; structure elucidation; ascidians natural products; alkyl sulfate; cytotoxic activity; structure elucidation; ascidians
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Supplementary material

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Imperatore, C.; Aiello, A.; D'Aniello, F.; Luciano, P.; Vitalone, R.; Meli, R.; Raso, G.M.; Menna, M. New Bioactive Alkyl Sulfates from Mediterranean Tunicates. Molecules 2012, 17, 12642-12650.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top