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New Bioactive Alkyl Sulfates from Mediterranean Tunicates
The NeaNat Group, Dipartimento di Chimica delle Sostanze Naturali, Università degli Studi di Napoli “Federico II”, Via D. Montesano 49, 80131, Napoli, Italy
C.S.I.A.S. (Centro Servizi Interdipartimentale di Analisi Strumentale), Università degli Studi di Napoli “Federico II”, Via D. Montesano 49, 80131, Napoli, Italy
Dipartimento di Farmacologia Sperimentale, Università degli Studi di Napoli “Federico II”, Via D. Montesano 49, 80131, Napoli, Italy
* Author to whom correspondence should be addressed.
Received: 29 September 2012; in revised form: 22 October 2012 / Accepted: 23 October 2012 / Published: 26 October 2012
Abstract: Chemical investigation of two species of marine ascidians, Aplidium elegans and Ciona edwardsii, collected in Mediterranean area, led to isolation of a series of alkyl sulfates (compounds 1–5) including three new molecules 1–3. Structures of the new metabolites have been elucidated by spectroscopic analysis. Based on previously reported cytotoxic activity of these type of molecules, compounds 1–3 have been tested for their effects on the growth of two cell lines, J774A.1 (BALB/c murine macrophages) and C6 (rat glioma) in vitro. Compounds 1 and 2 induced selective concentration-dependent mortality on J774A.1 cells.
Keywords: natural products; alkyl sulfate; cytotoxic activity; structure elucidation; ascidians
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MDPI and ACS Style
Imperatore, C.; Aiello, A.; D'Aniello, F.; Luciano, P.; Vitalone, R.; Meli, R.; Raso, G.M.; Menna, M. New Bioactive Alkyl Sulfates from Mediterranean Tunicates. Molecules 2012, 17, 12642-12650.
Imperatore C, Aiello A, D'Aniello F, Luciano P, Vitalone R, Meli R, Raso GM, Menna M. New Bioactive Alkyl Sulfates from Mediterranean Tunicates. Molecules. 2012; 17(11):12642-12650.
Imperatore, Concetta; Aiello, Anna; D'Aniello, Filomena; Luciano, Paolo; Vitalone, Rocco; Meli, Rosaria; Raso, Giuseppina M.; Menna, Marialuisa. 2012. "New Bioactive Alkyl Sulfates from Mediterranean Tunicates." Molecules 17, no. 11: 12642-12650.