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Molecules 2012, 17(11), 12642-12650; doi:10.3390/molecules171112642
Article

New Bioactive Alkyl Sulfates from Mediterranean Tunicates

1
, 1
, 1
, 2
, 1
, 3
, 3
 and 1,*
1 The NeaNat Group, Dipartimento di Chimica delle Sostanze Naturali, Università degli Studi di Napoli “Federico II”, Via D. Montesano 49, 80131, Napoli, Italy 2 C.S.I.A.S. (Centro Servizi Interdipartimentale di Analisi Strumentale), Università degli Studi di Napoli “Federico II”, Via D. Montesano 49, 80131, Napoli, Italy 3 Dipartimento di Farmacologia Sperimentale, Università degli Studi di Napoli “Federico II”, Via D. Montesano 49, 80131, Napoli, Italy
* Author to whom correspondence should be addressed.
Received: 29 September 2012 / Revised: 22 October 2012 / Accepted: 23 October 2012 / Published: 26 October 2012
(This article belongs to the Section Metabolites)
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Abstract

Chemical investigation of two species of marine ascidians, Aplidium elegans and Ciona edwardsii, collected in Mediterranean area, led to isolation of a series of alkyl sulfates (compounds 15) including three new molecules 13. Structures of the new metabolites have been elucidated by spectroscopic analysis. Based on previously reported cytotoxic activity of these type of molecules, compounds 13 have been tested for their effects on the growth of two cell lines, J774A.1 (BALB/c murine macrophages) and C6 (rat glioma) in vitro. Compounds 1 and 2 induced selective concentration-dependent mortality on J774A.1 cells.
Keywords: natural products; alkyl sulfate; cytotoxic activity; structure elucidation; ascidians natural products; alkyl sulfate; cytotoxic activity; structure elucidation; ascidians
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Imperatore, C.; Aiello, A.; D'Aniello, F.; Luciano, P.; Vitalone, R.; Meli, R.; Raso, G.M.; Menna, M. New Bioactive Alkyl Sulfates from Mediterranean Tunicates. Molecules 2012, 17, 12642-12650.

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