Molecules 2012, 17(10), 12187-12196; doi:10.3390/molecules171012187
Article

Synthesis and Herbicidal Activity of Substituted Pyrazole Isothiocyanates

1,2, 1,2, 3 and 1,2,* email
Received: 29 August 2012; in revised form: 8 October 2012 / Accepted: 9 October 2012 / Published: 17 October 2012
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Isothiocyanates and substituted pyrazoles were combined to form a series of novel isothiocyanates with highly effective herbicidal activity. The target compounds were analyzed by elemental analysis, 1H-NMR, EI-MS and IR spectroscopy. The synthesized compounds, particularly compounds 3-1 and 3-7, exhibited good herbicidal activities against four weeds. The EC50 values of compound 3-1 against Echinochloa crusgalli L., Cyperus iria L., Dactylis glomerata L., and Trifolium repens L. were 64.32, 65.83, 62.42, and 67.72 µg/mL, respectively. The EC50 values of compound 3-7 against E. crusgalli L., C. iria L., D. glomerata L., T. repens L. were 65.33, 64.90, 59.41 and 67.41 µg/mL, respectively. Compounds 3-1 and 3-7 may be further optimized as lead compounds for new herbicides.
Keywords: substituted pyrazoles; isothiocyanates; synthesis; herbicidal activity
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MDPI and ACS Style

Wu, H.; Feng, J.-T.; Lin, K.-C.; Zhang, X. Synthesis and Herbicidal Activity of Substituted Pyrazole Isothiocyanates. Molecules 2012, 17, 12187-12196.

AMA Style

Wu H, Feng J-T, Lin K-C, Zhang X. Synthesis and Herbicidal Activity of Substituted Pyrazole Isothiocyanates. Molecules. 2012; 17(10):12187-12196.

Chicago/Turabian Style

Wu, Hua; Feng, Jun-Tao; Lin, Kai-Chun; Zhang, Xing. 2012. "Synthesis and Herbicidal Activity of Substituted Pyrazole Isothiocyanates." Molecules 17, no. 10: 12187-12196.

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