Next Article in Journal
Bioactive Oleanane, Lupane and Ursane Triterpene Acid Derivatives
Previous Article in Journal
The Final Link: Tapping the Power of Chemical Genetics to Connect the Molecular and Biologic Functions of Mitotic Protein Kinases
Molecules 2012, 17(10), 12187-12196; doi:10.3390/molecules171012187

Synthesis and Herbicidal Activity of Substituted Pyrazole Isothiocyanates

1,2, 1,2, 3 and 1,2,*
Received: 29 August 2012 / Revised: 8 October 2012 / Accepted: 9 October 2012 / Published: 17 October 2012
View Full-Text   |   Download PDF [182 KB, uploaded 18 June 2014]   |   Browse Figure


Isothiocyanates and substituted pyrazoles were combined to form a series of novel isothiocyanates with highly effective herbicidal activity. The target compounds were analyzed by elemental analysis, 1H-NMR, EI-MS and IR spectroscopy. The synthesized compounds, particularly compounds 3-1 and 3-7, exhibited good herbicidal activities against four weeds. The EC50 values of compound 3-1 against Echinochloa crusgalli L., Cyperus iria L., Dactylis glomerata L., and Trifolium repens L. were 64.32, 65.83, 62.42, and 67.72 µg/mL, respectively. The EC50 values of compound 3-7 against E. crusgalli L., C. iria L., D. glomerata L., T. repens L. were 65.33, 64.90, 59.41 and 67.41 µg/mL, respectively. Compounds 3-1 and 3-7 may be further optimized as lead compounds for new herbicides.
Keywords: substituted pyrazoles; isothiocyanates; synthesis; herbicidal activity substituted pyrazoles; isothiocyanates; synthesis; herbicidal activity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
MDPI and ACS Style

Wu, H.; Feng, J.-T.; Lin, K.-C.; Zhang, X. Synthesis and Herbicidal Activity of Substituted Pyrazole Isothiocyanates. Molecules 2012, 17, 12187-12196.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here


Cited By

[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert