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Molecules 2012, 17(10), 12015-12022; doi:10.3390/molecules171012015
Article

Nukuhivensiums, Indolo[2,3-a]quinoliziniums from the Marquesan Plant Rauvolfia nukuhivensis

1
, 2
, 1
, 3,*  and 1,*
Received: 13 September 2012; in revised form: 7 October 2012 / Accepted: 9 October 2012 / Published: 12 October 2012
(This article belongs to the Section Metabolites)
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Abstract: The first phytochemical inspection of the Marquesan endemic plant Rauvolfia nukuhivensis led to the isolation and structure characterization of two new indolo[2,3‑a]quinolizinium derivatives named nukuhivensium (1) and N12-methyl-nukuhivensium (2). They feature an aromatic indolo[2,3-a]quinolizinium core, substituted at C-2 by a n-propyl group, which is unusual in this family of alkaloid derivatives. The structure elucidation was performed on the basis of NMR spectroscopy and especially by interpretation of 2D HMBC correlations. A biosynthetic pathway is proposed on the basis of known enzymatic transformations for this family of natural products. These compounds exhibited low antimicrobial activities.
Keywords: alkaloid; Rauvolfia; antimicrobial; indoles; biosynthesis alkaloid; Rauvolfia; antimicrobial; indoles; biosynthesis
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Martin, N.J.; Prado, S.; Lecellier, G.; Thomas, O.P.; Raharivelomanana, P. Nukuhivensiums, Indolo[2,3-a]quinoliziniums from the Marquesan Plant Rauvolfia nukuhivensis. Molecules 2012, 17, 12015-12022.

AMA Style

Martin NJ, Prado S, Lecellier G, Thomas OP, Raharivelomanana P. Nukuhivensiums, Indolo[2,3-a]quinoliziniums from the Marquesan Plant Rauvolfia nukuhivensis. Molecules. 2012; 17(10):12015-12022.

Chicago/Turabian Style

Martin, Nicolas J.; Prado, Soizic; Lecellier, Gael; Thomas, Olivier P.; Raharivelomanana, Phila. 2012. "Nukuhivensiums, Indolo[2,3-a]quinoliziniums from the Marquesan Plant Rauvolfia nukuhivensis." Molecules 17, no. 10: 12015-12022.



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