Molecules 2012, 17(10), 12015-12022; doi:10.3390/molecules171012015
Article

Nukuhivensiums, Indolo[2,3-a]quinoliziniums from the Marquesan Plant Rauvolfia nukuhivensis

1 Laboratory UMR 241 EIO, University of French Polynesia, 98702 Faa'a, Tahiti, French Polynesia 2 Laboratory UMR 7245 CNRS, National Museum of Natural History, 63 rue Buffon, 75005 Paris, France 3 Nice Institute of Chemistry UMR 7272 CNRS-PCRE, University of Nice-Sophia Antipolis, Parc Valrose, 06108 Nice, France
* Authors to whom correspondence should be addressed.
Received: 13 September 2012; in revised form: 7 October 2012 / Accepted: 9 October 2012 / Published: 12 October 2012
(This article belongs to the Section Natural Products)
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Abstract: The first phytochemical inspection of the Marquesan endemic plant Rauvolfia nukuhivensis led to the isolation and structure characterization of two new indolo[2,3‑a]quinolizinium derivatives named nukuhivensium (1) and N12-methyl-nukuhivensium (2). They feature an aromatic indolo[2,3-a]quinolizinium core, substituted at C-2 by a n-propyl group, which is unusual in this family of alkaloid derivatives. The structure elucidation was performed on the basis of NMR spectroscopy and especially by interpretation of 2D HMBC correlations. A biosynthetic pathway is proposed on the basis of known enzymatic transformations for this family of natural products. These compounds exhibited low antimicrobial activities.
Keywords: alkaloid; Rauvolfia; antimicrobial; indoles; biosynthesis

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MDPI and ACS Style

Martin, N.J.; Prado, S.; Lecellier, G.; Thomas, O.P.; Raharivelomanana, P. Nukuhivensiums, Indolo[2,3-a]quinoliziniums from the Marquesan Plant Rauvolfia nukuhivensis. Molecules 2012, 17, 12015-12022.

AMA Style

Martin NJ, Prado S, Lecellier G, Thomas OP, Raharivelomanana P. Nukuhivensiums, Indolo[2,3-a]quinoliziniums from the Marquesan Plant Rauvolfia nukuhivensis. Molecules. 2012; 17(10):12015-12022.

Chicago/Turabian Style

Martin, Nicolas J.; Prado, Soizic; Lecellier, Gael; Thomas, Olivier P.; Raharivelomanana, Phila. 2012. "Nukuhivensiums, Indolo[2,3-a]quinoliziniums from the Marquesan Plant Rauvolfia nukuhivensis." Molecules 17, no. 10: 12015-12022.

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